| Title: | Nontargeted urinary profiling strategy for endocrine-disrupting chemicals in women with ovarian malignancies |
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| Authors: | ID Plešnik, Helena (Author)
ID Rekar, Žan (Author)
ID Stevanović, Stefanela (Author)
ID Virant-Klun, Irma (Author)
ID Imamović-Kumalić, Senka (Author)
ID Sladič, Mateja (Author)
ID Mazej, Darja (Author)
ID Snoj Tratnik, Janja (Author)
ID Horvat, Milena (Author)
ID Kosjek, Tina (Author) |
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| Files: |  PDF - Presentation file, download (4,13 MB)
MD5: 3B2CEEBBD4F8B47E0B8136CCC085AFD8
 URL - Source URL, visit https://pubs.acs.org/doi/10.1021/acs.est.4c13290
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Endocrine-disrupting chemicals (EDCs), includingknown and unknown parent compounds, their metabolites, andtransformation products, are pervasive in daily life, posingincreasing risks to human health and the environment. Thisstudy employed a high-resolution mass spectrometry-basednontargeted screening approach, integrating polar (HILIC) andreversed-phase separations to expand the chemical space coverageand, supported by open-science tools and resources, evaluatedurinary chemical profiles to assess internal EDC exposure. Among106 annotated biomarkers of exposure, six exhibited significantlyhigher normalized intensities in patients with ovarian malignanciescompared to healthy controls (p < 0.05). This suggests theirgreater exposure to phthalates (diethylhexyl phthalate and diethylphthalate), pesticides (metolachlor metabolite and 4-nitrophenol), a UV filter (benzophenone-1), and an industrial byproduct (4-methyl-2-nitrophenol). These compounds may interfere with hormonal regulation, potentially contributing to cancer development.While these findings highlight potential differences in internal EDC exposure, the study primarily demonstrates the applicability ofnontargeted urinary profiling for chemical exposure assessment. By providing new insights into EDCs burden and its pathologicalimplications, this work contributes to advancing next-generation chemical risk assessment within the European Partnership for theAssessment of Risks from Chemicals initiative and supports the development of preventive strategies to mitigate environmentalcancer risks |
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| Keywords: | ovarian cancer, biomarkers, exposure, nontargeted screening, high-resolution mass spectrometry, analytical coverage, reversed-phase, HILIC |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 8380-8390 |
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| Numbering: | Vol. 59, issue 17 |
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| PID: | 20.500.12556/DiRROS-24499  |
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| UDC: | 61+502.1 |
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| ISSN on article: | 1520-5851 |
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| DOI: | 10.1021/acs.est.4c13290 |
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| COBISS.SI-ID: | 234015491 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 23. 4. 2025;
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| Publication date in DiRROS: | 02.12.2025 |
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| Views: | 133 |
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| Downloads: | 71 |
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