| Title: | UV-radiation and MC1R germline mutations are risk factors for the development of conventional and spitzoid melanomas in children and adolescents |
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| Authors: | ID Liebmann, Alexandra (Author)
ID Admard, Jakob (Author)
ID Armeanu-Ebinger, Sorin (Author)
ID Wild, Hannah (Author)
ID Abele, Michael (Author)
ID Gschwind, Axel (Author)
ID Seibel-Kelemen, Olga (Author)
ID Seitz, Christian (Author)
ID Bonzheim, Irina (Author)
ID Rieß, Olaf (Author)
ID Česen, Maja (Author), et al. |
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| Files: |  PDF - Presentation file, download (1017,17 KB)
MD5: FF60152174607CFD80E7BB45332A8A88
 URL - Source URL, visit https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00363-8/fulltext
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Background: Genomic characterisation has led to an improved understanding of adult melanoma. However, the aetiology of melanoma in children is still unclear and identifying the correct diagnosis and therapeutic strategies remains challenging. Methods: Exome sequencing of matched tumour-normal pairs from 26 paediatric patients was performed to study the mutational spectrum of melanomas. The cohort was grouped into different categories: spitzoid melanoma (SM), conventional melanoma (CM), and other melanomas (OT). Findings: In all patients with CM (n = 10) germline variants associated with melanoma were found in low to moderate melanoma risk genes: in 8 patients MC1R variants, in 2 patients variants in MITF, PTEN and BRCA2. Somatic BRAF mutations were detected in 60% of CMs, homozygous deletions of CDKN2A in 20%, TERTp mutations in 30%. In the SM group (n = 12), 5 patients carried at least one MC1R variant; somatic BRAF mutations were detected in 8.3%, fusions in 25% of the cases. No SM showed a homozygous CDKN2A deletion nor a TERTp mutation. In 81.8% of the CM/SM cases the UV damage signatures SBS7 and/or DBS1 were detected. The patient with melanoma arising in giant congenital nevus (CNM) demonstrated the characteristic NRAS Q61K mutation. Interpretation: UV-radiation and MC1R germline variants are risk factors in the development of conventional and spitzoid paediatric melanomas. Paediatric CMs share genomic similarities with adult CMs while the SMs differ genetically from the CM group. Consistent genetic characterization of all paediatric melanomas will potentially lead to better subtype differentiation, treatment, and prevention in the future. |
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| Keywords: | paediatric melanoma, exome sequencing, tumour-normal sequencing, rare paediatric tumours |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2023 |
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| Number of pages: | str. 1-26 |
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| Numbering: | Vol. 96, ǂ[article no.] ǂ104797 |
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| PID: | 20.500.12556/DiRROS-24458  |
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| UDC: | 616-053.2 |
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| ISSN on article: | 2352-3964 |
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| DOI: | 10.1016/j.ebiom.2023.104797 |
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| COBISS.SI-ID: | 221264899 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 7. 1. 2025;
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| Publication date in DiRROS: | 28.11.2025 |
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| Views: | 154 |
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| Downloads: | 73 |
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