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Title:Koencim Q10 kot prehransko dopolnilo in zdravilo
Authors:ID Žmitek, Janko (Author)
ID Žmitek, Katja (Author)
Files:.pdf PDF - Presentation file, download (242,04 KB)
MD5: C7E9EAB7A625D6F3864865DD68C1C1FA
 
Language:Slovenian
Typology:1.02 - Review Article
Organization:Logo NUTRIS - Institute of Nutrition
Abstract:Koencim Q10 (CoQ10) ima nenadomestljivo vlogo prenašalca elektronov med kompleksi mitohondrijske dihalne verige ter aktivnega nosilca protonov prek notranje mitohondrijske membrane, s oeimer sodeluje v procesu nastajanja gradienta protonov in sinteze ATP. CoQ10 je hkrati tudi edini endogeni maščobotopni antioksidant v telesu. Del ga zaužijemo tudi s hrano. Njegova biološka vloga temelji na redoks ravnotežju med (oksidirano) ubikinonsko in (reducirano) ubikinolno obliko, med katerima neprestano prehaja. Redoks stanje zaužitega CoQ10 (ubikinon / ubikinol) ne vpliva na njegovo funkcijo v telesu. Študije kažejo, da se koncentracije celokupnega CoQ10 v najaktivnejših telesnih organih s staranjem zmanjšujejo, raziskovalci pa so pokazali tudi pozitiven prispevek dodajanja CoQ10 pri razliČenih zdravstvenih stanjih. Ker se zaradi svojih fizikalnih lastnosti tako ubikinon kot ubikinol zelo slabo absorbirata iz prebavnega trakta, je potrebno posebno pozornost posvečati biodostopnosti proizvodov. Prvi veoeji korak za povečevanje biodostopnosti CoQ10 predstavlja razvoj oljnih suspenzij (mehkih kapsul) z ubikinonom in kasneje ubikinolom, nadaljnjega pa razvoj vodotopnih oblik CoQ10. Predstavljen je tudi pregled izdelkov s CoQ10 na slovenskem tržišču.
Keywords:koencim Q10, biorazpoložljivost, varnost, biodostopnost, biokinol, regulatorne celice, celična terapija
Publication status:Published
Publication version:Version of Record
Publication date:01.07.2009
Year of publishing:2009
Number of pages:str. 150-157
Numbering:Let. 60, št. 3
PID:20.500.12556/DiRROS-24345 New window
UDC:615
ISSN on article:0014-8229
COBISS.SI-ID:33506565 New window
Publication date in DiRROS:30.01.2026
Views:116
Downloads:36
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Record is a part of a journal

Title:Farmacevtski vestnik : strokovno glasilo slovenske farmacije
Shortened title:Farm. vestn.
Publisher:Slovensko farmacevtsko društvo
ISSN:0014-8229
COBISS.SI-ID:3105794 New window

Secondary language

Language:English
Title:Coenzyme Q10 as a dietary supplement and drug
Abstract:Coenzyme Q10 is a lipophilic compound playing an important role in the mitochondrial respiratory chain, where it acts as an electron carrier and as acarrier of proton transfer across membranes. It is also well known for its antioxidant properties. In the body CoQ10 mostly has an endogenous origin and is only partly derived by food. The biological role of CoQ10 is built on its redox equilibrium and continuous transformation between (oxidised) ubiquinone and (reduced) ubiquinol forms. Its function in the body is not affected by theform in which it is consumed. A decline in CoQ10 levels can be observed with increasing age, especially in the most active organs, while the beneficial effect of supplementation has been observed in many medical conditions. Due to its physical properties CoQ10 is very poorly absorbed from the gastrointestinal tract. Oil suspensions (soft-gel capsules) of ubiquinone and later ubiquionol represent the first important steps in increasing the bioavailability, while a further breakthrough was achieved with the development of water-soluble forms. An overview of CoQ10 products available onthe Slovenian market is presented.


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