| Title: | Long-term outcomes of reduced-dose bleomycin in electrochemotherapy for basal cell carcinoma in elderly patients |
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| Authors: | ID Grošelj, Aleš (Author)
ID Jamšek, Črt (Author)
ID Kranjc Brezar, Simona (Author)
ID Čemažar, Maja (Author)
ID Omerzel, Maša (Author)
ID Pušnik, Luka (Author)
ID Serša, Gregor (Author) |
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| Files: |  PDF - Presentation file, download (1,23 MB)
MD5: CEAA737C686B061EF4C459C8DB423C80
 URL - Source URL, visit https://www.nature.com/articles/s41598-025-93104-3
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Electrochemotherapy (ECT) is a minimally invasive treatment option for basal cell carcinoma (BCC), which is particularly advantageous in the elderly population. This study evaluated the long-term effects of treating BCC in older patients using ECT with a reduced dose of bleomycin (10,000 IU/m2) and compared the results to patients who received the standard dose of bleomycin (15,000 IU/m2). The retrospective analysis included 116 patients aged over 65 years with 257 histologically confirmed BCCs. Tumors were treated with either the standard dose (n = 82) or the reduced dose (n = 175) of bleomycin. The results showed that the recurrence rate was comparable between the groups, particularly in the first year after treatment. The reduced-dose group exhibited a greater recurrence rate after the first year, which may be attributed to a weaker local immune response due to the de-escalated dose of bleomycin. Nonetheless, administering a standard bleomycin dosage as a salvage treatment in the event of recurrence proved highly effective. These findings suggest that ECT with a reduced bleomycin dose is a viable option for treating BCC in elderly patients, particularly those with shorter life expectancy. |
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| Keywords: | bleomycin, electrochemotherapy, head and neck, nonmelanoma skin cancer |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 1-7 |
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| Numbering: | Vol. 15, no. 1 |
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| PID: | 20.500.12556/DiRROS-24311  |
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| UDC: | 616-006 |
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| ISSN on article: | 2045-2322 |
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| DOI: | 10.1038/s41598-025-93104-3 |
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| COBISS.SI-ID: | 234048259 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 23. 4. 2025;
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| Publication date in DiRROS: | 25.11.2025 |
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| Views: | 441 |
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| Downloads: | 151 |
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| Metadata: |    |
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