| Title: | Extracellular vesicle-derived bioactive molecules for corneal and ocular surface regeneration |
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| Authors: | ID Kolenc, Ana (Author)
ID Dimnik, Živa (Author)
ID Marzidovšek, Miha (Author)
ID Schollmayer, Petra (Author)
ID Hawlina, Marko (Author)
ID Maličev, Elvira (Author)
ID Lužnik Marzidovšek, Zala (Author) |
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| Files: |  PDF - Presentation file, download (1,39 MB)
MD5: 8723327DBA61684AE26FA8A5002A434D
 URL - Source URL, visit https://www.mdpi.com/2077-0383/14/15/5594
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| Language: | English |
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| Typology: | 1.02 - Review Article |
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| Organization: |  UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Cell-based therapies emerge as potential treatment options for various debilitating diseases. Preclinical research and clinical studies involving cells increased exponentially in the past decade. In addition to cell-based approaches, the use of extracellular vesicles (EVs), which are released by nearly all cell types, emerged as a promising cell-free alternative. Those approaches are also being explored in the field of ophthalmology. Several clinical trials involving EVs are underway to develop potential treatments for advanced ocular surface diseases, including corneal disorders, injuries, and dry eye disease. The cargo carried by EVs has been shown to include a diverse array of functional molecules such as transcription factors, cytokines, growth factors, mRNA, tRNA, rRNA, miRNA, and fragments of dsDNA. While the molecular composition of EVs is already well characterised, the specific activity of these molecules upon delivery to recipient cells remains poorly understood. In this review, we summarise recent studies investigating the bioactive molecules within EVs shown to influence or modulate cellular activity on the ocular surface. Among these, various miRNAs have most commonly been identified as therapeutic agents targeting distinct molecular pathways. The EVs studied were predominantly derived from various mesenchymal stem cells. |
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| Keywords: | extracellular vesicles, bioactive molecules, cornea, dry eye disease, miRNA, mesenchymal stem cells, ophthalmology |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 1-17 |
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| Numbering: | Vol. 14, iss. 15, [article no.] 5594 |
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| PID: | 20.500.12556/DiRROS-24274  |
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| UDC: | 617.7 |
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| ISSN on article: | 2077-0383 |
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| DOI: | 10.3390/jcm14155594 |
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| COBISS.SI-ID: | 245312259 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 11. 8. 2025;
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| Publication date in DiRROS: | 24.11.2025 |
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| Views: | 131 |
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| Downloads: | 66 |
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