| Title: | PET/CT and MR improve interobserver agreement in primary tumor determination for radiotherapy in esophageal squamous cell cancer |
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| Authors: | ID Šečerov Ermenc, Ajra (Author)
ID Peterlin, Primož (Author)
ID Velenik, Vaneja (Author)
ID Jeromen, Ana (Author)
ID But-Hadžić, Jasna (Author)
ID Anderluh, Franc (Author)
ID Šegedin, Barbara (Author) |
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| Files: |  URL - Source URL, visit https://pmc.ncbi.nlm.nih.gov/articles/PMC11941085/
 PDF - Presentation file, download (566,23 KB)
MD5: 7B39585C29DCF30B8606C6217DDFCA65
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  OI - Institute of Oncology
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| Abstract: | The aim of the study was to evaluate interobserver variability in the determination of the primary tumor for radiotherapy treatment planning in esophageal squamous cell carcinoma (ESCC). Methods: Sixteen patients with locally advanced ESCC were included in the analysis. In all patients positron emission tomography with computed tomography (PETC/CT) and magnetic resonance (MR) scans for radiotherapy planning were performed. Five experienced radiation oncologists delineated the primary tumor based on CT alone, MR alone, PET/CT, CT with fused MR and PET/CT with fused MR. Mean tumor volumes were calculated for each patient and imaging modality. The generalized conformity index (CIgen) was calculated to assess agreement in tumor determination. Results: The mean tumor volumes and CIgen for CT alone, MR alone, PET/CT, CT with fused MR and PET/CT with fused MR were 33.1 cm3, 30.2 cm3, 38.1 cm3, 31.9 cm3, 36.2 cm3 and 0.59, 0.64, 0.66, 0.63, 0.71, respectively. CIgen was significantly higher using PET/CT with fused MR compared to CT (p < 0.001) and PET/CT (p = 0.002) and using PET/CT compared to CT (alone) (p = 0.003). Conclusions: Our study showed higher agreement in primary tumor determination in ESCC using PET/CT compared to CT alone. Higher agreement was also found using PET/CT with fused MR compared to CT alone and PET/CT. |
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| Keywords: | magnetic resonance, positron emission tomography, squamous cell carcinoma, primary tumor |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 07.02.2025 |
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| Article acceptance date: | 07.03.2025 |
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| Publication date: | 11.03.2025 |
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| Place of publishing: | Basel |
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| Publisher: | MDPI, Basel, Switzerland |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 690-1-690-10 |
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| Numbering: | Vol. 15, no. 6 |
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| Source: | Basel, Switzerland |
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| PID: | 20.500.12556/DiRROS-24005  |
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| UDC: | 616-006 |
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| ISSN on article: | 2075-4418 |
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| DOI: | 10.3390/diagnostics15060690 |
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| COBISS.SI-ID: | 230835203 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 31. 3. 2025;
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| Publication date in DiRROS: | 26.11.2025 |
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| Views: | 114 |
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| Downloads: | 43 |
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