| Title: | Synthesis of a water-soluble BODIPY for targeting and assessing the function of endoplasmic reticulum |
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| Authors: | ID Tricomi, Jacopo (Author)
ID Biagiotti, Giacomo (Author)
ID Chastel, Tommy (Author)
ID Filiberti, Serena (Author)
ID Kokot, Hana, Institut "Jožef Stefan" (Author)
ID Mancusi, Francesca (Author)
ID Žežlina, Maja, Institut "Jožef Stefan" (Author)
ID Rajeh, Layal (Author)
ID Urbančič, Iztok, Institut "Jožef Stefan" (Author)
ID Bodin, Stéphane (Author) |
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| Files: |  URL - Source URL, visit https://pubs.acs.org/doi/pdf/10.1021/acsbiomedchemau.5c00142?ref=article_openPDF
 PDF - Presentation file, download (7,92 MB)
MD5: AA04E3F40A78B5047FF12EDA0395DFEB
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  IJS - Jožef Stefan Institute
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| Abstract: | We report here on a straightforward methodology to synthesize a new water-soluble fluorescent probe TrisBODIPY-OH 1 that contains three pH-independent hydrophilic arms. This probe has been prepared by exploiting a synthetic strategy that includes as a key step the combination of a Cu(I)-catalyzed azide−alkyne cycloaddition (CuAAC) and a Sonogashira cross-coupling in a sequential one-pot approach. Tris-BODIPY-OH 1 provides a significant advancement in the field by expanding the BODIPY toolbox with a biocompatible water-soluble probe, which can be used to specifically label and assess the function of the endoplasmic reticulum. |
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| Keywords: | BODIPY, Sonogashira, cross-coupling, azide-alkyne cycloaddition, endoplasmic reticulum, organelle labeling, chick chorioallantoic membrane model |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 04.06.2025 |
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| Article acceptance date: | 25.07.2025 |
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| Publication date: | 04.08.2025 |
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| Publisher: | American Chemical Society |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 895-905 |
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| Numbering: | Vol. 5, iss. 5 |
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| Source: | ZDA |
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| PID: | 20.500.12556/DiRROS-23976  |
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| UDC: | 547 |
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| ISSN on article: | 2694-2437 |
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| DOI: | 10.1021/acsbiomedchemau.5c00142 |
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| COBISS.SI-ID: | 255414531 |
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| Copyright: | © 2025 The Authors. |
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| Note: | Soavtorji: Giacomo Biagotti, Tommy Chastel, Serena Filiberti, Hana Kokot, Francesca Mancusi, Maja Žežlina, Layal Rajeh, Iztok Urbančič, Stéphane Bodin, idr.;
Nasl. z nasl. zaslona;
Opis vira z dne 30. 10. 2025;
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| Publication date in DiRROS: | 30.10.2025 |
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| Views: | 189 |
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| Downloads: | 94 |
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