| Title: | Cysteine cathepsins as regulators of the cytotoxicity of NK and T cells |
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| Authors: | ID Perišić, Milica, Institut "Jožef Stefan" (Author)
ID Sabotič, Jerica, Institut "Jožef Stefan" (Author)
ID Jewett, Anahid (Author)
ID Kos, Janko, Institut "Jožef Stefan" (Author) |
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| Files: |  URL - Source URL, visit http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00616/full
URL - Source URL, visit http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00616/full
 PDF - Presentation file, download (5,16 MB)
MD5: 41D4ACA8BFDF7A9D1F7A0B944F2700EC
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| Language: | English |
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| Typology: | 1.02 - Review Article |
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| Organization: |  IJS - Jožef Stefan Institute
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| Abstract: | Cysteine cathepsins are lysosomal peptidases involved at different levels in the processes of the innate and adaptive immune responses. Some, such as cathepsins B, L, and H are expressed constitutively in most immune cells. In cells of innate immunity they play a role in cell adhesion and phagocytosis. Other cysteine cathepsins are expressed more specifically. Cathepsin X promotes dendritic cell maturation, adhesion of macrophages, and migration of T cells. Cathepsin S is implicated in major histocompatibility complex class II antigen presentation, whereas cathepsin C, expressed in cytotoxic T lymphocytes and natural killer (NK) cells, is involved in processing pro-granzymes into proteolytically active forms, which trigger cell death in their target cells. The activity of cysteine cathepsins is controlled by endogenous cystatins, cysteine protease inhibitors. Of these, cystatin F is the only cystatin that is localized in endosomal/lysosomal vesicles. After proteolytic removal of its N-terminal peptide, cystatin F becomes a potent inhibitor of cathepsin C with the potential to regulate pro-granzyme processing and cell cytotoxicity. This review is focused on the role of cysteine cathepsins and their inhibitors in the molecular mechanisms leading to the cytotoxic activity of T lymphocytes and NK cells in order to address new possibilities for regulation of their function in pathological processes. |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 10.10.2014 |
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| Article acceptance date: | 18.11.2014 |
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| Publication date: | 02.12.2014 |
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| Publisher: | Frontiers |
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| Year of publishing: | 2014 |
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| Number of pages: | art. 616 |
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| Numbering: | Vol. 5 |
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| Source: | Švica |
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| PID: | 20.500.12556/DiRROS-23482  |
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| UDC: | 577.27:616-097 |
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| ISSN on article: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2014.00616 |
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| COBISS.SI-ID: | 3788913 |
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| Copyright: | © 2014 Periši ́c Nanut, Sabotiˇc, Jewett and Kos. |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 11. 12. 2014;
Članek v pdf obsega 10 str.;
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| Publication date in DiRROS: | 04.09.2025 |
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| Views: | 285 |
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| Downloads: | 211 |
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