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Title:Inducirane pluripotentne matične celice pri odkrivanju in vrednotenju zdravilnih učinkovin
Authors:ID Rotman Primec, Jaka (Author)
ID Krajšek, Zala (Author)
ID Urbančič, Dunja (Author)
Files:.pdf PDF - Presentation file, download (1,99 MB)
MD5: AAFA52C476603C830B575F3D4F7B032D
 
Language:Slovenian
Typology:1.02 - Review Article
Organization:Logo SFD - Slovenian Pharmaceutical Society
Abstract:Inducirane pluripotentne matične celice so v zadnjih letih postale pomembno orodje za odkrivanje zdravilnih učinkovin, saj ponujajo bistvene prednosti pred tradicionalnimi modeli, kot so primarne celice, rakave celične linije in živalski modeli. Pridobimo jih z reprogramiranjem somatskih celic v pluripotentno stanje, kar omogoča njihovo diferenciacijo v različne tipe celic ob ohranjanju dedne informacije posameznika. Pri uporabi induciranih pluripotentnih matičnih celic za odkrivanje zdravilnih učinkovin je na voljo več modelov, vključno z dvodimenzionalnimi kulturami, enostavnejšimi tridimenzionalnimi modeli in naprednejšimi modeli – organi na čipu. Tovrstni modeli omogočajo natančnejšo oceno toksičnosti in učinkovitosti zdravilnih učinkovin, njihovih medsebojnih interakcij ter proučevanje mehanizmov bolezni. Izzivi, s katerimi se soočamo ob uporabi induciranih pluripotentnih matičnih celic, so: njihova nezadostna zrelost, variabilnost med pridobljenimi celičnimi linijami in visoki stroški, kar trenutno omejuje njihovo širšo uporabo v farmaciji. Kljub tem omejitvam imajo inducirane pluripotentne matične celice velik potencial za razvoj personaliziranih oblik zdravljenja in odkrivanje novih terapevtskih pristopov.
Keywords:celični modeli in vitro, inducirane pluripotentne matične celice, odkrivanje novih zdravilnih učinkovin, predklinične študije
Publication status:Published
Publication version:Version of Record
Publication date:01.01.2025
Year of publishing:2025
Number of pages:str. 39-48
Numbering:Letn. 76, Št. 1
PID:20.500.12556/DiRROS-22882 New window
UDC:576.3:615.015
ISSN on article:0014-8229
COBISS.SI-ID:230988547 New window
Publication date in DiRROS:08.07.2025
Views:379
Downloads:138
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Record is a part of a journal

Title:Farmacevtski vestnik : strokovno glasilo slovenske farmacije
Shortened title:Farm. vestn.
Publisher:Slovensko farmacevtsko društvo
ISSN:0014-8229
COBISS.SI-ID:3105794 New window

Licences

License:CC BY-NC 4.0, Creative Commons Attribution-NonCommercial 4.0 International
Link:http://creativecommons.org/licenses/by-nc/4.0/
Description:A creative commons license that bans commercial use, but the users don’t have to license their derivative works on the same terms.

Secondary language

Language:English
Title:Induced pluripotent stem cells in drug discovery
Abstract:Induced pluripotent stem cells have become an important tool for drug discovery in recent years, offering significant advantages over traditional models, such as primary cells, cancer cell lines, and animal models. These cells are derived by reprogramming somatic cells into a pluripotent state, allowing differentiation into various cell types while retaining the genetic information of the individual. In drug discovery, models from induced pluripotent stem cells encompass twodimensional cultures, three-dimensional models, and more sophisticated organs-on-a-chip. These advanced models enable more accurate assessment of drug toxicity and efficacy, compound interactions, as well as detailed studies of disease mechanisms. however, challenges in application of induced pluripotent stem cells remain, including limited cellular maturity, variability across obtained cell lines, and high costs, which currently restrict their broader use in the pharmaceutical field. Despite these limitations, induced pluripotent stem cells hold great promise for the development of personalised therapies and the discovery of novel therapeutic approaches.


Collection

This document is a part of these collections:
  1. Farmacevtski vestnik

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