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Title:Infuzijske reakcije po parenteralni aplikaciji citostatikov na Onkološkem inštitutu Ljubljana med leti 2019-2023
Authors:ID Eberl, Andreja (Author)
ID Kadiš, Lea (Author)
ID Kerec Kos, Mojca (Author)
Files:.pdf PDF - Presentation file, download (350,88 KB)
MD5: F7C76AFF6ECB2B6C4870501F92548B9D
 
Language:Slovenian
Typology:1.01 - Original Scientific Article
Organization:Logo SFD - Slovenian Pharmaceutical Society
Abstract:Nekatera protitumorna zdravila, ki jih apliciramo parenteralno, predstavljajo tveganje za pojav infuzijskih reakcij, ki so pogost vzrok prekinitev zdravljenja pri bolnikih z rakom. Izvedli smo retrospektivno analizo infuzijskih reakcij na Onkološkem inštitutu Ljubljana med leti 2019 in 2023. V raziskavo smo vključili vse bolnike, ki so v navedenem časovnem obdobju med parenteralno aplikacijo citostatikov doživeli infuzijsko reakcijo. Med bolniki, ki so prejeli 14 različnih citostatičnih učinkovin, je bila infuzijska reakcija poročana v 403 primerih. Najvišjo incidenco infuzijskih reakcij (7,42 %) smo zabeležili pri pegilirani liposomalni obliki doksorubicina, najnižjo pa pri ciklofosfamidu (0,06 %). Infuzijske reakcije so bile pri antraciklinih in taksanih najpogostejše v prvem oziroma drugem ciklu terapije, pri platinovih spojinah pa v poznejših ciklih. Pri večini zdravilnih učinkovin, razen pri platinovih spojinah, so bolniki po pojavu infuzijske reakcije še isti dan nadaljevali s kemoterapijo, pri čemer so se infuzijske reakcije redko ponovile.
Keywords:incidenca, infuzijska reakcija, neželeni učinki, parenteralna kemoterapija
Publication status:Published
Publication version:Version of Record
Publication date:01.03.2025
Year of publishing:2025
Number of pages:str. 3-9
Numbering:Letn. 76, Št. 1
PID:20.500.12556/DiRROS-22879 New window
UDC:616-006
ISSN on article:0014-8229
COBISS.SI-ID:230892803 New window
Publication date in DiRROS:08.07.2025
Views:304
Downloads:122
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Record is a part of a journal

Title:Farmacevtski vestnik : strokovno glasilo slovenske farmacije
Shortened title:Farm. vestn.
Publisher:Slovensko farmacevtsko društvo
ISSN:0014-8229
COBISS.SI-ID:3105794 New window

Licences

License:CC BY-NC 4.0, Creative Commons Attribution-NonCommercial 4.0 International
Link:http://creativecommons.org/licenses/by-nc/4.0/
Description:A creative commons license that bans commercial use, but the users don’t have to license their derivative works on the same terms.

Secondary language

Language:English
Title:Infusion reactions following parenteral administration of cytostatic drugs at the Institute of Oncology Ljubljana between 2019 and 2023
Abstract:Several anticancer therapies administered by the parenteral route carry a risk for infusion reactions, which are common cause of treatment interruption for patients with cancer. The study included all patients who experienced an infusion reaction during parenteral administration of chemotherapy during this period. In patients who received 14 different cytostatic drugs, infusion reactions occurred in 403 cases. The highest incidence of infusion reactions (7.42%) was observed with pegylated liposomal doxorubicin, and the lowest with cyclophosphamide (0.06%). Infusion reactions occurred most frequently during the first or second cycle of therapy with anthracyclines and taxanes and in later cycles with platinum compounds. For most therapeutic agents, except for platinum compounds, patients were able to continue chemotherapy on the same day after the onset of an infusion reaction, with recurrence being rare.


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This document is a part of these collections:
  1. Farmacevtski vestnik

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