| Title: | Risk factors for severe sting reactions and side effects during venom immunotherapy |
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| Authors: | ID Sturm, Gunter (Author)
ID Schadelbauer, Eva (Author)
ID Marta, Giorgia (Author)
ID Bonadonna, Patrizia (Author)
ID Košnik, Mitja, Univerzitetna klinika za pljučne bolezni in alergijo Golnik (Author) |
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| Files: |  URL - Source URL, visit https://www.jaci-inpractice.org/article/S2213-2198(24)00845-6/pdf
URL - Source URL, visit https://www.jaci-inpractice.org/article/S2213-2198(24)00845-6/fulltext
 PDF - Presentation file, download (347,09 KB)
MD5: A919AF8BF15BF70CC576762EEAE0A9AC
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| Language: | English |
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| Typology: | 1.02 - Review Article |
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| Organization: |  UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
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| Abstract: | Understanding the risk factors leading to severe systemic sting reactions (SSRs) is crucial for initiating venom immunotherapy (VIT) and for educating affected individuals and their families. Some of these risk factors are well established, some are no longer considered risk factors, and some remain controversial. Well-established risk factors for severe SSRs include clonal mast cell disease, high baseline serum tryptase, and advanced age. The absence of skin symptoms and the rapid onset of symptoms are indicators of severe SSRs. Recent publications indicate that antihypertensive treatment and stings in the head and neck area are not risk factors for severe SSRs. VIT is the only available treatment that can potentially prevent further anaphylactic reactions. Although rare and generally manageable, individuals undergoing VIT may experience systemic adverse events (sAEs). More sAEs are expected in patients undergoing bee VIT compared with vespid VIT. The role of elevated baseline serum tryptase as a risk factor for sAEs remains debated, but if it is a factor, the risk is increased by only about 1.5-fold. Rapid updosing protocols, depending on the specific regimen, can also be associated with more sAEs. Severe initial SSRs, antihypertensive medication, high skin test reactivity, and high specific IgE levels are not risk factors for sAEs. |
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| Keywords: | immunology, anaphylaxis, Hymenoptera venom allergy, risk factors, severe systemic sting reactions, side effects, venom immunotherapy |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Article acceptance date: | 05.08.2024 |
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| Publication date: | 20.08.2024 |
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| Publisher: | Elsevier |
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| Year of publishing: | 2025 |
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| Number of pages: | str. 17-23 |
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| Numbering: | Vol. 13, iss. 1 |
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| Source: | The journal of allergy and clinical immunology. In practice |
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| PID: | 20.500.12556/DiRROS-22835  |
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| UDC: | 616-097 |
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| ISSN on article: | 2213-2201 |
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| DOI: | 10.1016/j.jaip.2024.08.025 |
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| COBISS.SI-ID: | 204938243 |
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| Copyright: | © 2024 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 22. 8. 2024;
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| Publication date in DiRROS: | 02.07.2025 |
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| Views: | 440 |
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| Downloads: | 357 |
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