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Title:Črevesni mikrobiom pri bolnikih z rakom
Authors:ID Ivkovič, Jakob (Author)
ID Unk, Mojca (Author)
Files:.pdf PDF - Presentation file, download (289,63 KB)
MD5: B3C7955377B0680962E56190E6639C95
 
Language:Slovenian
Typology:1.02 - Review Article
Organization:Logo OI - Institute of Oncology
Abstract:Črevesni mikrobiom predstavlja genetsko zasnovo vseh mikrobov, ki obstajajo v človeškem prebavnem traktu in vsebuje okoli 38 bilijonov mikroorganizmov, ki kodira več kot tri milijone genov. Razvoj novih tehnik molekularnega sekvenciranja je omogočil poglobljeno raziskovanje človeškega mikrobioma, ki je vpleten v presnovo hranil, zdravil, vzdržuje celovito bariero črevesne sluznice, varuje pred patogenimi mikroorganizmi in lahko spreminja imunski odziv gostitelja. Vedno več je dokazov, da je črevesni mikrobiom vpleten v razvoj nekaterih malignih bolezni in vpliva na učinkovitost onkološkega zdravljenja, predvsem na imunoterapijo. Sedanje razumevanje številnih zapletenih interakcij med črevesnim mikrobiomom, gostiteljevim imunskim sistemom, prehrano, zdravili in malignimi celicami temelji na manjših retrospektivnih in opazovalnih raziskavah. Namen tega prispevka je pregled razpoložljivih podatkov o mikrobiomu in naše dosedanje razumevanje vloge črevesnega mikrobioma pri bolnikih z rakom.
Keywords:črevesni mikrobiom, kancerogeneza, imunoterapija, zaviralci imunskih nadzornih točk
Publication status:Published
Publication version:Version of Record
Publication date:01.12.2024
Year of publishing:2024
Number of pages:str. 40-49
Numbering:Letn. 28, št. 2
PID:20.500.12556/DiRROS-22449 New window
UDC:616-006
ISSN on article:1408-1741
DOI:10.25670/oi2024-009on New window
COBISS.SI-ID:208991747 New window
Note:Besedilo v slov.;
Publication date in DiRROS:21.05.2025
Views:410
Downloads:195
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Record is a part of a journal

Title:Onkologija
Shortened title:Onkologija
Publisher:Onkološki inštitut
ISSN:1408-1741
COBISS.SI-ID:65324032 New window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

Language:English
Title:Gut microbiome in cancer patients
Abstract:The gut microbiome represents the genetic makeup of all the microbes in the human digestive tract. It contains about 38 trillion microorganisms with more than three million genes. With the development of new sequencing techniques, in-depth research of the human microbiome, which is involved in the metabolism of nutrients, and drugs, maintains a barrier of the intestinal mucosa, protects against pathogenic microorganisms, and can alter the host's immune response. There is compounding evidence, that the microbiome is involved in the development of certain malignant diseases and affects the effectiveness of oncological treatment, specifically on immunotherapy. Currently, the understanding of the numerous complex interactions between the gut microbiome, the host immune system, diet, drugs, and malignant cells is based on smaller retrospective and observational studies. This paper aims to review the available data on the microbiome and our current understanding of the human microbiome's role in cancer patients.
Keywords:gut microbiome, cancerogenesis, immunotherapy, immune checkpoint inhibitors


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