| Title: | Prospective observational study of COVID-19 vaccination in patients with thoracic malignancies : adverse events, breakthrough infections and survival outcomes |
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| Authors: | ID Janžič, Urška, Univerzitetna klinika za pljučne bolezni in alergijo Golnik (Author)
ID Janžič, Andrej (Author)
ID Agbarya, Abed (Author)
ID Bidovec, Urška, Univerzitetna klinika za pljučne bolezni in alergijo Golnik (Author)
ID Mohorčič, Katja, Univerzitetna klinika za pljučne bolezni in alergijo Golnik (Author)
ID Čakš, Marina (Author)
ID Korošec, Peter, Univerzitetna klinika za pljučne bolezni in alergijo Golnik (Author)
ID Rijavec, Matija, Univerzitetna klinika za pljučne bolezni in alergijo Golnik (Author)
ID Škof, Erik (Author) |
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| Files: |  URL - Source URL, visit https://www.mdpi.com/2227-9059/12/3/535
 PDF - Presentation file, download (1,28 MB)
MD5: 94910CE6B577307EF810D4966A0FBB14
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
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| Abstract: | Abstract: Due to the devastating COVID-19 pandemic, a preventive tool in the form of vaccination was introduced. Thoracic cancer patients had one of the highest rates of morbidity and mortality due to COVID-19 disease, but the lack of data about the safety and effectiveness of vaccines in this population triggered studies like ours to explore these parameters in a cancer population. Out of 98 patients with thoracic malignancies vaccinated per protocol, 60–75% experienced some adverse events (AE) after their first or second vaccination, most of them were mild and did not interfere with their daily activities. Out of 17 severe AEs reported, all but one were resolved shortly after vaccination. No significant differences were noted considering AE occurrence between different cancer therapies received after the first or second vaccination dose, p = 0.767 and p = 0.441, respectively. There were 37 breakthrough infections either after the first (1), second (13) or third (23) vaccine dose. One patient died as a direct consequence of COVID-19 infection and respiratory failure, and another after disease progression with simultaneous severe infection. Eight patients had moderate disease courses, received antiviral therapies and survived without consequences. Vaccination did not affect the time to disease progression or death from underlying cancer. |
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| Keywords: | thoracic malignancies, cancer therapy, COVID-19 vaccination, adverse events, breakthrough infection |
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| Publication version: | Version of Record |
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| Submitted for review: | 15.02.2024 |
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| Article acceptance date: | 26.02.2024 |
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| Publication date: | 27.02.2024 |
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| Publisher: | MDPI AG, 2013- |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 535-1-535-12 |
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| Numbering: | Vol. 12 |
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| Source: | Biomedicines |
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| PID: | 20.500.12556/DiRROS-21754  |
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| UDC: | 616-006 |
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| ISSN on article: | 2227-9059 |
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| DOI: | 10.3390/biomedicines12030535 |
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| COBISS.SI-ID: | 189077251 |
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| Copyright: | © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 15. 3. 2024;
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| Publication date in DiRROS: | 24.03.2025 |
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| Views: | 695 |
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| Downloads: | 393 |
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