| Title: | A "crossomics" study analysing variability of different components in peripheral blood of health caucasoid individuals |
|---|
| Authors: | ID Gruden, Kristina (Author)
ID Hren, Matjaž (Author)
ID Herman, Ana (Author)
ID Blejec, Andrej (Author)
ID Albrecht, Tanja (Author)
ID Selbig, Joachim (Author)
ID Bauer, Chris (Author)
ID Schuchardt, Jochannes (Author)
ID Or-Guil, Michal (Author)
ID Zupančič, Klemen (Author)
ID Švajger, Urban (Author)
ID Štabuc, Borut (Author)
ID Ihan, Alojz (Author)
ID Kopitar, Andreja Nataša (Author)
ID Ravnikar, Maja (Author)
ID Knežević, Miomir (Author)
ID Rožman, Primož (Author)
ID Jeras, Matjaž (Author) |
|---|
| Files: |  URL - Source URL, visit http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0028761
 PDF - Presentation file, download (558,83 KB)
MD5: 497BA1503B59E221A76BAEA6B7AA6634
URL - Source URL, visit https://doi.org/10.1371/journal.pone.0028761
|
|---|
| Language: | English |
|---|
| Typology: | 1.01 - Original Scientific Article |
|---|
| Organization: |  NIB - National Institute of Biology
|
|---|
| Abstract: | Background: Different immunotherapy approaches for the treatment of cancer andautoimmune diseases are being developed and tested in clinical studies worldwide. Their resulting complex experimental data should be properly evaluated, therefore reliable normal healthy control baseline values are indispensable. Methodology/Principal Findings: To assess intra- and inter-individual variability of various biomarkers, peripheral blood of 16 age and gender equilibrated healthy volunteers was sampled on 3 different days within a period of one month. Complex ććcrossomicsćć analyses of plasma metabolite profiles, antibody concentrations and lymphocyte subset counts as well as whole genome expression profiling in CD4+T and NK cells were performed. Some of the observed age, gender and BMI dependences are in agreement with the existing knowledge, like negative correlation between sex hormone levels and age or BMI related increase in lipids and soluble sugars. Thus we can assume that the distribution of all 39.743 analysed markers is well representing the normal Caucasoid population. All lymphocyte subsets, 20% of metabolites and less than 10% of genes, were identified as highly variable in our dataset. Conclusions/Significance: Our study shows that the intra-individual variability was at least two-fold lower compared to the inter-individual one at all investigated levels, showing the importance of personalised medicine approach from yet another perspective. |
|---|
| Publication status: | Published |
|---|
| Publication version: | Version of Record |
|---|
| Publication date: | 12.01.2012 |
|---|
| Year of publishing: | 2012 |
|---|
| Number of pages: | str. e28761 |
|---|
| Numbering: | Vol. 7, no. 1 |
|---|
| PID: | 20.500.12556/DiRROS-21608  |
|---|
| UDC: | 616.1 |
|---|
| ISSN on article: | 1932-6203 |
|---|
| COBISS.SI-ID: | 3192689 |
|---|
| Note: | Obj. online, januar 12, 2012;
|
|---|
| Publication date in DiRROS: | 04.03.2025 |
|---|
| Views: | 510 |
|---|
| Downloads: | 541 |
|---|
| Metadata: |    |
|---|
|
:
|
Copy citation |
|---|
| | | | Share: |  |
|---|
Hover the mouse pointer over a document title to show the abstract or click
on the title to get all document metadata. |
