Title: | Graph topological transformations in space-filling cell aggregates |
---|
Authors: | ID Sarkar, Tanmoy (Author) ID Krajnc, Matej, Institut Jožef Stefan (Author) |
Files: | URL - Source URL, visit https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012089
PDF - Presentation file, download (2,62 MB) MD5: 146825D477A40550AA92B4820DCDC0B4
|
---|
Language: | English |
---|
Typology: | 1.01 - Original Scientific Article |
---|
Organization: | IJS - Jožef Stefan Institute
|
---|
Abstract: | Cell rearrangements are fundamental mechanisms driving large-scale deformations of living tissues. In three-dimensional (3D) space-filling cell aggregates, cells rearrange through local topological transitions of the network of cell-cell interfaces, which is most conveniently described by the vertex model. Since these transitions are not yet mathematically properly formulated, the 3D vertex model is generally difficult to implement. The few existing implementations rely on highly customized and complex software-engineering solutions, which cannot be transparently delineated and are thus mostly non-reproducible. To solve this outstanding problem, we propose a reformulation of the vertex model. Our approach, called Graph Vertex Model (GVM), is based on storing the topology of the cell network into a knowledge graph with a particular data structure that allows performing cell-rearrangement events by simple graph transformations. Importantly, when these same transformations are applied to a two-dimensional (2D) polygonal cell aggregate, they reduce to a well-known T1 transition, thereby generalizing cell-rearrangements in 2D and 3D space-filling packings. This result suggests that the GVM’s graph data structure may be the most natural representation of cell aggregates and tissues. We also develop a Python package that implements GVM, relying on a graph-database-management framework Neo4j. We use this package to characterize an order-disorder transition in 3D cell aggregates, driven by active noise and we find aggregates undergoing efficient ordering close to the transition point. In all, our work showcases knowledge graphs as particularly suitable data models for structured storage, analysis, and manipulation of tissue data. |
---|
Keywords: | 3D vertex models, cell, software-engineering |
---|
Publication status: | Published |
---|
Publication version: | Version of Record |
---|
Submitted for review: | 24.11.2023 |
---|
Article acceptance date: | 19.04.2024 |
---|
Publication date: | 14.05.2024 |
---|
Publisher: | PLOS |
---|
Year of publishing: | 2024 |
---|
Number of pages: | str. 1-24 |
---|
Numbering: | 5, [article no.] e1012089, 20 |
---|
Source: | ZDA |
---|
PID: | 20.500.12556/DiRROS-20301 ![Link is opened in a new window New window](teme/dirros/img/NovoOkno.png) |
---|
UDC: | 577.3:53 |
---|
ISSN on article: | 1553-7358 |
---|
DOI: | 10.1371/journal.pcbi.1012089 ![Link is opened in a new window New window](teme/dirros/img/NovoOkno.png) |
---|
COBISS.SI-ID: | 195652099 ![Link is opened in a new window New window](teme/dirros/img/NovoOkno.png) |
---|
Note: | Nasl. z nasl. zaslona;
Opis vira z dne 16. 5. 2024;
|
---|
Publication date in DiRROS: | 03.09.2024 |
---|
Views: | 13 |
---|
Downloads: | 1327 |
---|
Metadata: | ![Export as DC-RDF DC-RDF](teme/dirros/img/icon_dc_rdf.gif) |
---|
:
|
Copy citation |
---|
| | | Share: | ![Bookmark and Share](teme/dirros/img/addtoany.png) |
---|
Hover the mouse pointer over a document title to show the abstract or click
on the title to get all document metadata. |