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Title:CXCR4 antagonists as stem cell mobilizers and therapy sensitizers for acute myeloid leukemia and glioblastoma?
Authors:ID Hira, Vashendriya V. V. (Author)
ID Noorden, Cornelis J. F. van (Author)
ID Molenaar, Remco J. (Author)
Files:URL URL - Source URL, visit https://www.mdpi.com/2079-7737/9/2/31
 
.pdf PDF - Presentation file, download (1,51 MB)
MD5: 141860D0097387337E12B9B19A571323
 
URL URL - Source URL, visit https://doi.org/10.3390/biology9020031
 
Language:English
Typology:1.03 - Other scientific articles
Organization:Logo NIB - National Institute of Biology
Abstract:Glioblastoma is the most aggressive and malignant primary brain tumor in adults and has a poor patient survival of only 20 months after diagnosis. This poor patient survival is at least partly caused by glioblastoma stem cells (GSCs), which are slowly-dividing and therefore therapy-resistant. GSCs are localized in protective hypoxic peri-arteriolar niches where these aforementioned stemness properties are maintained. We previously showed that hypoxic peri-arteriolar GSC niches in human glioblastoma are functionally similar to hypoxic peri-arteriolar hematopoietic stem cell (HSC) niches in human bone marrow. GSCs and HSCs express the receptor C-X-C receptor type 4 (CXCR4), which binds to the chemoattractant stromal-derived factor-1α (SDF-1α), which is highly expressed in GSC niches in glioblastoma and HSC niches in bone marrow. This receptor–ligand interaction retains the GSCs/HSCs in their niches and thereby maintains their slowly-dividing state. In acute myeloid leukemia (AML), leukemic cells use the SDF-1α–CXCR4 interaction to migrate to HSC niches and become slowly-dividing and therapy-resistant leukemic stem cells (LSCs). In this communication, we aim to elucidate how disruption of the SDF-1α–CXCR4 interaction using the FDA-approved CXCR4 inhibitor plerixafor (AMD3100) may be used to force slowly-dividing cancer stem cells out of their niches in glioblastoma and AML. Ultimately, this strategy aims to induce GSC and LSC differentiation and their sensitization to therapy.
Keywords:glioblastoma, glioblastoma stem cells, niches, acute myeloid leukemia, hematopoietic stem cells, bone marrow, C-X-C receptor type 4, stromal-derived factor-1 [alpha], plerixafor
Publication status:Published
Publication version:Version of Record
Publication date:12.02.2020
Year of publishing:2020
Number of pages:str. 1-10
Numbering:Vol. 9, iss. 31
PID:20.500.12556/DiRROS-20163 New window
UDC:577
ISSN on article:2079-7737
DOI:10.3390/biology9020031 New window
COBISS.SI-ID:40521221 New window
Note:Nasl. z nasl. zaslona; Opis vira z dne 30. 3. 2020;
Publication date in DiRROS:06.08.2024
Views:532
Downloads:560
Metadata:XML DC-XML DC-RDF
:
HIRA, Vashendriya V. V., NOORDEN, Cornelis J. F. van and MOLENAAR, Remco J., 2020, CXCR4 antagonists as stem cell mobilizers and therapy sensitizers for acute myeloid leukemia and glioblastoma? Biology [online]. 2020. Vol. 9, no. 31, p. 1–10. [Accessed 21 April 2025]. DOI 10.3390/biology9020031. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=20163
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Record is a part of a journal

Title:Biology
Shortened title:Biology
Publisher:MDPI AG
ISSN:2079-7737
COBISS.SI-ID:523004441 New window

Document is financed by a project

Funder:Other - Other funder or multiple funders
Funding programme:the Dutch Cancer Society
Project number:UVA 2014-6839
Funder:Other - Other funder or multiple funders
Funding programme:the Dutch Cancer Society
Project number:UVA 2016.1-10460
Funder:Other - Other funder or multiple funders
Name:the Fondation pour la Recherche Nuovo-Soldati 2019

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

Language:Slovenian
Keywords:glioblastoma, matične celice, glioblastoma, akutna mielonična levkemija, kostni mozeg


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