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Title:Titanium dioxide in our everyday life : is it safe?
Authors:ID Skočaj, Matej (Author)
ID Filipič, Metka (Author)
ID Nunić, Jana (Author)
ID Novak, Saša (Author)
Files:.pdf PDF - Presentation file, download (800,38 KB)
MD5: FEC15193623F86674168FC6A1B06731C
 
URL URL - Source URL, visit https://doi.org/10.2478/v10019-011-0037-0
 
Language:English
Typology:1.02 - Review Article
Organization:Logo NIB - National Institute of Biology
Abstract:Background. Titanium dioxide (TiO2) is considered as an inert and safe material and has been used in many applications for decades. However, with the development of nanotechnologies TiO2 nanoparticles, with numerous novel and useful properties, are increasingly manufactured and used. Therefore increased human and environmental exposure can be expected, which has put TiO2 nanoparticles under toxicological scrutiny. Mechanistic toxicological studies show that TiO2 nanoparticles predominantly cause adverse effects via induction of oxidative stress resulting in cell damage, genotoxicity, inflammation, immune response etc. The extent and type of damage strongly depends on physical and chemical characteristics of TiO2 nanoparticles, which govern their bioavailability and reactivity. Based on the experimental evidence from animal inhalation studies TiO2 nanoparticles are classified as "possible carcinogenic to humans" by the International Agency for Research on Cancer and as occupational carcinogen by the National Institute for Occupational Safety and Health. The studies on dermal exposure to TiO2 nanoparticles, which is in humans substantial through the use of sunscreens, generally indicate negligible transdermal penetration; however data are needed on long-term exposure and potential adverse effects of photo-oxidation products. Although TiO2 is permitted as an additive (E171) in food and pharmaceutical products we do not have reliable data on its absorption, distribution, excretion and toxicity on oral exposure. TiO2 may also enter environment, and while it exerts low acute toxicity to aquatic organisms, upon long-term exposure it induces a range of sub-lethal effects. Conclusions. Until relevant toxicological and human exposure data that would enable reliable risk assessment are obtained, TiO2 nanoparticles should be used with great care.
Publication status:Published
Publication version:Version of Record
Publication date:01.12.2011
Year of publishing:2011
Number of pages:str. 227-247, I
Numbering:Vol. 45, no. 4
PID:20.500.12556/DiRROS-20145 New window
UDC:54
ISSN on article:1318-2099
DOI:10.2478/v10019-011-0037-0 New window
COBISS.SI-ID:25291815 New window
Note:Soavtorji: Metka Filipič, Jana Petković, Saša Novak;
Publication date in DiRROS:06.08.2024
Views:482
Downloads:266
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SKOČAJ, Matej, FILIPIČ, Metka, NUNIĆ, Jana and NOVAK, Saša, 2011, Titanium dioxide in our everyday life : is it safe? Radiology and oncology [online]. 2011. Vol. 45, no. 4, p. 227–247, i. [Accessed 21 April 2025]. DOI 10.2478/v10019-011-0037-0. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=20145
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 New window

Document is financed by a project

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:P2-0084-2009
Name:Nanostrukturni materiali
Funder:ARIS - Slovenian Research and Innovation Agency
Project number:P1-0245-2009
Name:Ekotoksiologija, toksikološka genomika in karcinogeneza

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

Language:Slovenian
Title:Titanijev dioksid v vsakdanji uporabi. Je varen?


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