| Title: | Nanoparticles for hyperthermic therapy : synthesis strategies and applications in glioblastoma |
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| Authors: | ID Verma, Jyoti (Author)
ID Lal, Sumit (Author)
ID Noorden, Cornelis J. F. van (Author) |
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| Files: |  URL - Source URL, visit http://dx.doi.org/10.2147/IJN.S57501
 PDF - Presentation file, download (2,20 MB)
MD5: 3178E1CF1F610BE1223F46D072007A4D
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| Language: | English |
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| Typology: | 1.02 - Review Article |
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| Organization: |  NIB - National Institute of Biology
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| Abstract: | Glioblastoma multiforme (GBM) is the most common and most aggressive malignant primary brain tumor in humans. Current GBM treatment includes surgery, radiation therapy, and chemotherapy, sometimes supplemented with novel therapies. Despite recent advances, survival of GBM patients remains poor. Major challenges in GBM treatment are drug delivery across the blood–brain barrier, restriction of damage to healthy brain tissues, and limitation of resistance to therapies. This article reviews recent advances in the application of magnetic nanoparticles (MNPs), gold nanorods (GNRs), and carbon nanotubes (CNTs) for hyperthermia ablation of GBM. First, the article introduces GBM, its current treatment, and hyperthermia as a potential modality for the management of GBM. Second, it introduces MNPs, GNRs, and CNTs as inorganic agents to induce hyperthermia in GBM. Third, it discusses different methodologies for synthesis of each inorganic agent. Finally, it reviews in vitro and in vivo studies in which MNPs, GNRs, and CNTs have been applied for hyperthermia ablation and drug delivery in GBM. |
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| Keywords: | hyperthermia, targeted drug delivery, SPIONs, gold nanorods, carbon nanotubes |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 10.06.2014 |
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| Year of publishing: | 2014 |
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| Number of pages: | str. 2863-2877 |
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| Numbering: | Vol. 9, iss. 1 |
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| PID: | 20.500.12556/DiRROS-20142  |
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| UDC: | 577 |
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| ISSN on article: | 1178-2013 |
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| DOI: | 10.2147/IJN.S57501 |
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| COBISS.SI-ID: | 4649295 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 16. 3. 2018;
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| Publication date in DiRROS: | 06.08.2024 |
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| Views: | 291 |
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| Downloads: | 212 |
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