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Title:Bioactive peptides from venoms against glioma progression
Authors:ID Majc, Bernarda (Author)
ID Novak, Metka (Author)
ID Lah Turnšek, Tamara (Author)
ID Križaj, Igor (Author)
Files:.pdf PDF - Presentation file, download (2,07 MB)
MD5: 8FF101987CF0E7CD97831B943526AEBF
 
URL URL - Source URL, visit https://doi.org/10.3389/fonc.2022.965882
 
Language:English
Typology:1.02 - Review Article
Organization:Logo NIB - National Institute of Biology
Abstract:Venoms are complex mixtures of different molecules and ions. Among them, bioactive peptides have been found to affect cancer hallmarks, such as cell proliferation, cell invasion, cell migration, and can also modulate the immune response of normal and cancer-bearing organisms. In this article, we review the mechanisms of action on these cancer cell features, focusing on bioactive peptides being developed as potential therapeutics for one of the most aggressive and deadly brain tumors, glioblastoma (GB). Novel therapeutic approaches applying bioactive peptides may contribute to multiple targeting of GB and particularly of GB stem cells. Bioactive peptides selectively target cancer cells without harming normal cells. Various molecular targets related to the effects of bioactive peptides on GB have been proposed, including ion channels, integrins, membrane phospholipids and even immunomodulatory treatment of GB. In addition to therapy, some bioactive peptides, such as disintegrins, can also be used for diagnostics or are used as labels for cytotoxic drugs to specifically target cancer cells. Given the limitations described in the last section, successful application in cancer therapy is rather low, as only 3.4% of such peptides have been included in clinical trials and have passed successfully phases I to III. Combined approaches of added bioactive peptides to standard cancer therapies need to be explored using advanced GB in vitro models such as organoids. On the other hand, new methods are also being developed to improve translation from research to practice and provide new hope for GB patients and their families.
Publication status:Published
Publication version:Version of Record
Publication date:29.08.2022
Year of publishing:2022
Number of pages:str. 1-14
Numbering:Vol. 12
PID:20.500.12556/DiRROS-20100 New window
UDC:577
ISSN on article:2234-943X
DOI:10.3389/fonc.2022.965882 New window
COBISS.SI-ID:119389187 New window
Note:Nasl. z nasl. zaslona; Opis vira z dne 28. 8. 2022; št. članka: 965882;
Publication date in DiRROS:05.08.2024
Views:503
Downloads:286
Metadata:XML DC-XML DC-RDF
:
MAJC, Bernarda, NOVAK, Metka, LAH TURNŠEK, Tamara and KRIŽAJ, Igor, 2022, Bioactive peptides from venoms against glioma progression. Frontiers in oncology [online]. 2022. Vol. 12, p. 1–14. [Accessed 21 April 2025]. DOI 10.3389/fonc.2022.965882. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=20100
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Record is a part of a journal

Title:Frontiers in oncology
Shortened title:Front. oncol.
Publisher:Frontiers Editorial Office
ISSN:2234-943X
COBISS.SI-ID:1601583 New window

Document is financed by a project

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:P1-0245-2019
Name:Ekotoksiologija, toksikološka genomika in karcinogeneza
Funder:ARIS - Slovenian Research and Innovation Agency
Project number:P1-0207-2020
Name:Toksini in biomembrane
Funder:Other - Other funder or multiple funders
Funding programme:Young Researcher grant
Project number:10040137

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

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