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Title:Mixtures of Chemical Pollutants at European Legislation Safety Concentrations: How Safe are They?
Authors:ID Carvalho, Raquel Negrão (Author)
ID Aruqwe, Augustine (Author)
ID Ait-Aissa, Selim (Author)
ID Bado-Nilles, Anne (Author)
ID Balzamo, Stefania (Author)
ID Baun, Anders (Author)
ID Belkin, Shimshon (Author)
ID Blaha, Ludek (Author)
ID Brion, Francois (Author)
ID Conti, Daniela (Author)
ID Flander-Putrle, Vesna (Author)
ID Turk, Valentina (Author)
Files:URL URL - Source URL, visit http://toxsci.oxfordjournals.org/content/early/2014/06/23/toxsci.kfu118.abstract?sid=d8381fd4-bf03-4904-92c7-b67ce34bb084
 
.pdf PDF - Presentation file, download (4,50 MB)
MD5: DB5A991CD2D7BDFC0047E3CB060855C8
 
URL URL - Source URL, visit https://doi.org/10.1093/toxsci/kfu118
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo NIB - National Institute of Biology
Abstract:The risk posed by complex chemical mixtures in the environment to wildlife and humans is increasingly debated, but has been rarely tested under environmentally relevant scenarios. To address this issue, two mixtures of 14 or 19 substances of concern (pesticides, pharmaceuticals, heavy metals, polyaromatic hydrocarbons, a surfactant, and a plasticizer), each present at its safety limit concentration imposed by the European legislation, were prepared and tested for their toxic effects. The effects of the mixtures were assessed in 35 bioassays, based on 11 organisms representing different trophic levels. A consortium of 16 laboratories was involved in performing the bioassays. The mixtures elicited quantifiable toxic effects on some of the test systems employed, including i) changes in marine microbial composition, ii) microalgae toxicity, iii) immobilization in the crustacean Daphnia magna, iv) fish embryo toxicity, v) impaired frog embryo development, and vi) increased expression on oxidative stress-linked reporter genes. Estrogenic activity close to regulatory safety limit concentrations was uncovered by receptor-binding assays. The results highlight the need of precautionary actions on the assessment of chemical mixtures even in cases where individual toxicants are present at seemingly harmless concentrations.
Keywords:morje, analizna kemija, biologija, evtrofikacija, hranilne snovi, fitoplankton, onesnaževanje, Piranski zaliv
Geographic coverage:Jadransko morje;
Publication status:Published
Publication version:Version of Record
Publication date:12.09.2014
Year of publishing:2014
Number of pages:str. 218-233
Numbering:Vol. 141, issue 1
PID:20.500.12556/DiRROS-20004 New window
UDC:543
ISSN on article:1096-6080
DOI:10.1093/toxsci/kfu118 New window
COBISS.SI-ID:3160655 New window
Publication date in DiRROS:02.08.2024
Views:475
Downloads:393
Metadata:XML DC-XML DC-RDF
:
CARVALHO, Raquel Negrão, ARUQWE, Augustine, AIT-AISSA, Selim, BADO-NILLES, Anne, BALZAMO, Stefania, BAUN, Anders, BELKIN, Shimshon, BLAHA, Ludek, BRION, Francois, CONTI, Daniela, FLANDER-PUTRLE, Vesna and TURK, Valentina, 2014, Mixtures of Chemical Pollutants at European Legislation Safety Concentrations: How Safe are They? Toxicological sciences [online]. 2014. Vol. 141, no. 1, p. 218–233. [Accessed 28 March 2025]. DOI 10.1093/toxsci/kfu118. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=20004
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Record is a part of a journal

Title:Toxicological sciences
Shortened title:Toxicol. sci.
Publisher:Academic Press
ISSN:1096-6080
COBISS.SI-ID:1494037 New window

Document is financed by a project

Funder:EC - European Commission
Project number:265721
Name:Rationally Designed Aquatic Receptors integrated in label-free biosensor platforms for remote surveillance of toxins and pollutants
Acronym:RADAR
Funder:Other - Other funder or multiple funders
Funding programme:French Ministry for Ecology and Sustainable Development
Project number:P181 DRC50

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License:CC BY-NC 4.0, Creative Commons Attribution-NonCommercial 4.0 International
Link:http://creativecommons.org/licenses/by-nc/4.0/
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