| Title: | Mixtures of Chemical Pollutants at European Legislation Safety Concentrations: How Safe are They? |
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| Authors: | ID Carvalho, Raquel Negrão (Author)
ID Aruqwe, Augustine (Author)
ID Ait-Aissa, Selim (Author)
ID Bado-Nilles, Anne (Author)
ID Balzamo, Stefania (Author)
ID Baun, Anders (Author)
ID Belkin, Shimshon (Author)
ID Blaha, Ludek (Author)
ID Brion, Francois (Author)
ID Conti, Daniela (Author)
ID Flander-Putrle, Vesna (Author)
ID Turk, Valentina (Author) |
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| Files: |  URL - Source URL, visit http://toxsci.oxfordjournals.org/content/early/2014/06/23/toxsci.kfu118.abstract?sid=d8381fd4-bf03-4904-92c7-b67ce34bb084
 PDF - Presentation file, download (4,50 MB)
MD5: DB5A991CD2D7BDFC0047E3CB060855C8
URL - Source URL, visit https://doi.org/10.1093/toxsci/kfu118
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  NIB - National Institute of Biology
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| Abstract: | The risk posed by complex chemical mixtures in the environment to wildlife and humans is increasingly debated, but has been rarely tested under environmentally relevant scenarios. To address this issue, two mixtures of 14 or 19 substances of concern (pesticides, pharmaceuticals, heavy metals, polyaromatic hydrocarbons, a surfactant, and a plasticizer), each present at its safety limit concentration imposed by the European legislation, were prepared and tested for their toxic effects. The effects of the mixtures were assessed in 35 bioassays, based on 11 organisms representing different trophic levels. A consortium of 16 laboratories was involved in performing the bioassays. The mixtures elicited quantifiable toxic effects on some of the test systems employed, including i) changes in marine microbial composition, ii) microalgae toxicity, iii) immobilization in the crustacean Daphnia magna, iv) fish embryo toxicity, v) impaired frog embryo development, and vi) increased expression on oxidative stress-linked reporter genes. Estrogenic activity close to regulatory safety limit concentrations was uncovered by receptor-binding assays. The results highlight the need of precautionary actions on the assessment of chemical mixtures even in cases where individual toxicants are present at seemingly harmless concentrations. |
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| Keywords: | morje, analizna kemija, biologija, evtrofikacija, hranilne snovi, fitoplankton, onesnaževanje, Piranski zaliv |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 12.09.2014 |
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| Year of publishing: | 2014 |
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| Number of pages: | str. 218-233 |
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| Numbering: | Vol. 141, issue 1 |
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| PID: | 20.500.12556/DiRROS-20004  |
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| UDC: | 543 |
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| ISSN on article: | 1096-6080 |
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| DOI: | 10.1093/toxsci/kfu118 |
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| COBISS.SI-ID: | 3160655 |
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| Publication date in DiRROS: | 02.08.2024 |
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| Views: | 364 |
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| Downloads: | 277 |
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| Metadata: |    |
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