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Title:Stress tolerance of three opportunistic black yeasts
Authors:ID Zajc Žunič, Janja (Author)
ID Gostinčar, Cene (Author)
ID Lenassi, Metka (Author)
ID Gunde-Cimerman, Nina (Author)
Files:.pdf PDF - Presentation file, download (1,00 MB)
MD5: CD9B3BD05F7AC62DD2BF87B51159C1F9
 
URL URL - Source URL, visit https://doi.org/10.14720/abs.61.2.15890
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo NIB - National Institute of Biology
Abstract:Many species of black yeasts can survive extremely harsh conditions and can quickly adapt to novel environments. These traits were proposed to have a role in the ability of some fungal species tocolonise indoor habitats inhospitable for majority of microorganisms, and to cause (opportunistic)infections in humans. In order to better understand the stress tolerance of black yeasts and thereby their opportunism, we focused our research on the three model black yeasts: the polyextremotolerant Au-reobasidium melanogenum and Exophiala dermatitidis, and the extremely halotolerant Hortaeawerneckii. These black yeasts are shown to thrive at temperatures, salinities, pH values and, H2O2 concentrations that inhibit growth of mesophilic species. Most importantly, unlike their close relatives they can not only grow, but also synthesize siderophores (E. dermatitidis) or degradeproteins (A. melanogenum) at 37 °C - traits that are crucial for pathogenesis in humans. These results support the hypothesis that the ability to cope with various environmental stresses is linked to the opportunistic behaviour of fungi. Therefore, better understanding of the connections between the stress-tolerant biology of black fungi and their ability to cause disease is needed, in particular due to their changing interactions with humans and their emerging pathogenicity.
Keywords:melanised fungi, temperature, NaCl, pH tolerance, ROS, oligotrophism, proteolytic activity, capsule
Publication status:Published
Publication version:Version of Record
Publication date:01.12.2018
Year of publishing:2018
Number of pages:str. 15-27
Numbering:Vol. 61, št. 2
PID:20.500.12556/DiRROS-19989 New window
UDC:579
ISSN on article:1408-3671
COBISS.SI-ID:4939855 New window
Note:Besedilo v angl.;
Publication date in DiRROS:01.08.2024
Views:553
Downloads:273
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ZAJC ŽUNIČ, Janja, GOSTINČAR, Cene, LENASSI, Metka and GUNDE-CIMERMAN, Nina, 2018, Stress tolerance of three opportunistic black yeasts. Acta biologica slovenica : ABS [online]. 2018. Vol. 61, no. 2, p. 15–27. [Accessed 21 April 2025]. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=19989
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Record is a part of a journal

Title:Acta biologica slovenica : ABS
Shortened title:Acta biol. slov.
Publisher:Društvo biologov Slovenije
ISSN:1408-3671
COBISS.SI-ID:68526592 New window

Document is financed by a project

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:P1-0170-2018
Name:Molekulski mehanizmi uravnavanja celičnih procesov v povezavi z nekaterimi boleznimi pri človeku
Funder:ARIS - Slovenian Research and Innovation Agency
Project number:P1-0207-2015
Name:Toksini in biomembrane
Funder:ARIS - Slovenian Research and Innovation Agency
Project number:Z7-7436-2016
Name:Na stres tolerantne kvasovke iz rodu Aureobasidium: uporaba v biološki kontroli nekaterih rastlinskih bolezni

Licences

License:CC BY-SA 4.0, Creative Commons Attribution-ShareAlike 4.0 International
Link:http://creativecommons.org/licenses/by-sa/4.0/
Description:This Creative Commons license is very similar to the regular Attribution license, but requires the release of all derivative works under this same license.

Secondary language

Language:Slovenian
Title:Toleranca na stres pri treh oportunističnih črnih kvasovkah
Abstract:Mnoge vrste črnih kvasovk lahko preživijo ekstremne razmere in se hitro prilagajajo novim okoljem. Te lastnosti imajo vlogo pri sposobnosti nekaterih vrst gliv, da lahko kolonizirajo negostoljubne habitate v notranjosti stavb in povzročijo (oportunistične) okužbe pri ljudeh. Raziskali smo toleranco na stres treh oportunističnih črnih kvasovk: poliekstremotolerantnih kvasovk Aureobasidium melanogenum in Exophiala dermatitidis ter izjemno halotolerantne kvasovke Hortaea werneckii. Vse tri črne kvasovke uspevajo pri temperaturah, koncentracijah NaCl, pH vrednostih in koncentracijah H2O2, ki zavrejo rast mezofilnih vrst. Še več, te vrste lahko v na-sprotju s svojimi bližnjimi sorodniki ne le rastejo, temveč tudi sintetizirajo siderofore (E. dermatitidis) in razgrajujejo proteine (A. melanogenum) pri 37 °C, kar sta pomembni lastnosti za patogenezo pri ljudeh. Ti rezultati se skladajo s hipotezo, da je sposobnost toleriranja različnih okoljskih stresov povezana z oportunističnim značajem gliv. Prav zato moramo bolje razumeti povezavo med biologijo tolerance na stres črnih gliv in njihovo sposobnostjo povzročanja bolezni, zlasti zaradi njihove spreminjajoče se interakcije z ljudmi in njihove porajajoče se patogenosti.
Keywords:melanizirane glive, termotoleranca, NaCl, pH toleranca, oksidativni stres, oligotrofizem, proteolitična aktivnost, kapsula


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