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Title:Imunohistokemična analiza izražanja glukokortikoidnih receptorjev pri zgodnjem raku dojk in njihov vpliv na odgovor na zdravljenje z neoadjuvantno sistemsko terapijo
Authors:ID Sraka, Marjetka (Author)
ID Gazić, Barbara (Author)
ID Drev, Primož (Author)
ID Grašič-Kuhar, Cvetka (Author)
Files:.pdf PDF - Presentation file, download (7,50 MB)
MD5: AA394E43386F8F4DA1D58908C54E12AA
 
Language:Slovenian
Typology:1.01 - Original Scientific Article
Organization:Logo OI - Institute of Oncology
Abstract:Glukokortikoidni receptor (GR) je različno izražen na tumorskih in imunskih celicah raka dojk, njegova izraženost pa je morda odvisna od molekularnega podtipa raka dojk, prav tako njegova izraženost morda vpliva na odgovor na neoad-juvantno sistemsko terapijo. Naš namen je vpeljati zanesljivo imunohistokemično barvanje s protitelesi proti GR, drugi namen pa je oceniti izraženost GR na vzorcih raka dojk in preučiti, ali se ta izraža različno pri različnih podtipih in ali njegova izraženost vpliva na odgovor na neoadjuvantno sistemsko terapijo.
Keywords:rak dojk, neoadjuvantno sistemsko zdravljenje, glukokortikoidni receptor
Publication status:Published
Publication version:Version of Record
Publication date:01.06.2024
Publisher:Onkolološki inštitut
Year of publishing:2024
Number of pages:str. 18-27
Numbering:Letn. 28, št. 1
Source:Ljubljana
PID:20.500.12556/DiRROS-19898 New window
UDC:618.1
ISSN on article:1408-1741
DOI:10.25670/oi2024-002on New window
COBISS.SI-ID:200299267 New window
Copyright:by Authors
Publication date in DiRROS:26.07.2024
Views:365
Downloads:172
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Record is a part of a journal

Title:Onkologija
Shortened title:Onkologija
Publisher:Onkološki inštitut
ISSN:1408-1741
COBISS.SI-ID:65324032 New window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:30.06.2024

Secondary language

Language:English
Title:Immunohistochemical analysis of glucocorticoid receptor expression in early breast cancer and its influence on response to treatment with neoadjuvant systemic therapy
Abstract:The glucocorticoid receptor (GR) is differentially expressed on tumour and immune cells in breast cancer, and its expression may depend on the molecular subtype of the cancer, and it may also inf luence the response to neoadjuvant systemic therapy. Our primary aim is to introduce reliable immunohistochemical staining with anti-GR antibodies, and our second aim is to evaluate the expression of GR in breast cancer samples and to study whether it is expressed differently in different subtypes and whether its expression has an impact on the response to neoadjuvant systemic therapy.


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