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Title:Cognitive functioning in a cohort of high-grade glioma patients
Authors:ID Škufca Smrdel, Andreja Cirila (Author)
ID Podlesek, Anja (Author)
ID Skoblar Vidmar, Marija (Author)
ID Markovič, Jana (Author)
ID Jereb, Jana (Author)
ID Kuzma, Manja (Author)
ID Smrdel, Uroš (Author)
Files:.pdf PDF - Presentation file, download (649,88 KB)
MD5: 4F00321D156A5DDC415E8343CFCBC7B6
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo OI - Institute of Oncology
Abstract:High grade gliomas are associated with cognitive problems. The aim of the study was to investigate cognitive functioning in a cohort of patients with high grade glioma, according to isocitrate dehydrogenase (IDH) and methyl guanine methyl transferase (MGMT) status and other clinical characteristics. The patients with the high-grade glioma treated in Slovenia in given period of time were included in study. Postoperatively they completed neuropsychological assessment consisting of Slovenian Verbal Learning Test, Slovenian Controlled Oral Word Association Test, Trail Making Test Part A and B and self-evaluation questionnaire. We analysed results (z-scores and dichotomized results) also according to IDH mutation and MGMT methylation. We examined differences between groups using T-test, Mann-Whitney U, χ2 and Kendall's Tau tests. Out of 275 patients in the cohort, we included 90. Forty-six percent of patients were unable to participate due to poor performance status and other conditions related to tumour. Patients with the IDH mutation were younger, with better performance status, larger proportions of grade III tumours and MGMT methylation. In this group cognitive functioning is significantly better in the domains of immediate recall, short delayed recall and delayed recall, and in the fields of executive functioning and recognition. There were no differences in cognitive functioning in regard to MGMT status. Grade III tumours were associated with more frequent MGMT methylation. Self-assessment proved week tool, associated only with immediate recall. We found no differences in cognitive functioning according to MGMT status, but cognition was better when IDH mutation was present. In a cohort study of patients with high-grade glioma, almost half were unable to participate in a study, which points to an overrepresentation of patients with better cognitive functioning in the research.
Keywords:cognition, high grade glioma, IDH1 mutation
Publication status:Published
Publication version:Version of Record
Publication date:01.01.2023
Publisher:Association of Radiology and Oncology
Year of publishing:2023
Number of pages:str. 201-210
Numbering:Vol. 57, no. 2
Source:Ljubljana
PID:20.500.12556/DiRROS-19833 New window
UDC:159.955
ISSN on article:1318-2099
DOI:10.2478/raon-2023-0009 New window
COBISS.SI-ID:159014147 New window
Copyright:by Authors
Publication date in DiRROS:25.07.2024
Views:509
Downloads:175
Metadata:XML DC-XML DC-RDF
:
ŠKUFCA SMRDEL, Andreja Cirila, PODLESEK, Anja, SKOBLAR VIDMAR, Marija, MARKOVIČ, Jana, JEREB, Jana, KUZMA, Manja and SMRDEL, Uroš, 2023, Cognitive functioning in a cohort of high-grade glioma patients. Radiology and oncology [online]. 2023. Vol. 57, no. 2, p. 201–210. [Accessed 4 April 2025]. DOI 10.2478/raon-2023-0009. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=19833
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 New window

Secondary language

Language:Slovenian
Keywords:kognicija, visoko maligni gliomi, mutacije IDH1


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