| Title: | Real-world outcomes, treatment patterns and T790M testing rates in non-small cell lung cancer patients treated with first-line first- or second-generation epidermal growth factor receptor tyrosine kinase inhibitors from the Slovenian cohort of the REFLECT study |
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| Authors: | ID Turnšek, Nina (Author)
ID Devjak, Rok (Author)
ID Edelbaher, Natalija (Author)
ID Osrajnik, Ilonka (Author)
ID Unk, Mojca (Author)
ID Vidovič, Dušanka (Author)
ID Jerič, Tina (Author)
ID Janžič, Urška (Author) |
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| Files: |  PDF - Presentation file, download (543,78 KB)
MD5: BEF2987F0DFD84362AB6D8BD229C973F
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  OI - Institute of Oncology
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| Abstract: | Background. Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are effective treatments for EGFR mutation-positive (EGFRm) non-small cell lung cancer (NSCLC). However, routine clinical practice is different between countries/institutions. Patients and methods. The REFLECT study (NCT04031898) is a retrospective medical chart review that explored real-life treatment and outcomes of EGFRm NSCLC patients receiving first-line (1L) first-/second-generation (1G/2G) EGFR TKIs in 8 countries. This study included adult patients with documented advanced/metastatic EGFRm NSCLC with 1L 1G/2G EGFR TKIs initiated between Jan 2015 – Jun 2018. We reviewed data on clinical characteristics, treatments, EGFR/T790M testing patterns, and survival outcomes. Here, we report data from 120 medical charts in 3 study sites from Slovenia. Results. The Slovenian cohort (median age 70 years, 74% females) received 37% erlotinib, 32% afatinib, 31% gefitinib. At the time of data collection, 94 (78%) discontinuations of 1L TKI, and 89 (74%) progression events on 1L treatment were reported. Among patients progressing on 1L, 73 (82%) were tested for T790M mutation yielding 50 (68%) positive results, and 62 (85%) received 2L treatment. 82% of patients received osimertinib. Attrition rate between 1L and 2L was 10%. The median (95% CI) real-world progression free survival on 1L EGFR TKIs was 15.6 (12.6, 19.2) months; median overall survival (95% CI) was 28.9 (25.0, 34.3) months. Conclusions. This real-world study provides valuable information about 1G/2G EGFR TKIs treatment outcomes and attrition rates in Slovenian EGFRm NSCLC patients. The reduced attrition rate and improved survival outcomes empha-size the importance of 1L treatment decision. |
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| Keywords: | real-world study, non-small cell lung cancer, epidermal growth factor receptor, lung cancer |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 01.09.2022 |
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| Publisher: | Association of Radiology and Oncology |
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| Year of publishing: | 2022 |
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| Number of pages: | str. 371-379 |
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| Numbering: | Vol. 56, no. 3 |
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| Source: | Ljubljana |
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| PID: | 20.500.12556/DiRROS-19797  |
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| UDC: | 616.24-006 |
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| ISSN on article: | 1318-2099 |
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| DOI: | 10.2478/raon-2022-0025 |
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| COBISS.SI-ID: | 118793219 |
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| Copyright: | by Authors |
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| Note: | Soavtorji: Rok Devjak, Natalija Edelbaher, Ilonka Osrajnik, Mojca Unk, Dusanka Vidovic, Tina Jeric, Urska Janzic;
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| Publication date in DiRROS: | 25.07.2024 |
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| Views: | 881 |
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| Downloads: | 349 |
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