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Title:Common gene expression patterns in environmental model organisms exposed to engineered nanomaterials : a meta-analysis
Authors:ID Burkard, Michael (Author)
ID Betz, Alexander (Author)
ID Schirmer, Kristin (Author)
ID Županič, Anže (Author)
Files:.pdf PDF - Presentation file, download (1,97 MB)
MD5: 3F12B189B616CE6F9B7A26351D5B376D
 
URL URL - Source URL, visit https://doi.org/10.1021/acs.est.9b05170
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo NIB - National Institute of Biology
Abstract:The use of omics is gaining importance in the field of nanoecotoxicology; an increasing number of studies are aiming to investigate the effects and modes of action of engineered nanomaterials (ENMs) in this way. However, a systematic synthesis of the outcome of such studies regarding common responses and toxicity pathways is currently lacking. We developed an R-scripted computational pipeline to perform reanalysis and functional analysis of relevant transcriptomic data sets using a common approach, independent from the ENM type, and across different organisms, including Arabidopsis thaliana, Caenorhabditis elegans, and Danio rerio. Using the pipeline that can semiautomatically process data from different microarray technologies, we were able to determine the most common molecular mechanisms of nanotoxicity across extremely variable data sets. As expected, we found known mechanisms, such as interference with energy generation, oxidative stress, disruption of DNA synthesis, and activation of DNA-repair but also discovered that some less-described molecular responses to ENMs, such as DNA/RNA methylation, protein folding, and interference with neurological functions, are present across the different studies. Results were visualized in radar charts to assess toxicological response patterns allowing the comparison of different organisms and ENM types. This can be helpful to retrieve ENM-related hazard information and thus fill knowledge gaps in a comprehensive way in regard to the molecular underpinnings and mechanistic understanding of nanotoxicity.
Keywords:gene expression, nanomaterials
Publication status:Published
Publication version:Version of Record
Publication date:22.11.2019
Year of publishing:2020
Number of pages:str. 335-344
Numbering:Vol. 54, no. 1
PID:20.500.12556/DiRROS-19503 New window
UDC:577.2
ISSN on article:0013-936X
DOI:10.1021/acs.est.9b05170 New window
COBISS.SI-ID:5246799 New window
Publication date in DiRROS:19.07.2024
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Downloads:213
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Record is a part of a journal

Title:Environmental science & technology
Shortened title:Environ. sci. technol.
Publisher:American Chemical Society
ISSN:0013-936X
COBISS.SI-ID:5141765 New window

Document is financed by a project

Funder:EC - European Commission
Project number:686239
Name:Performance testing, calibration and implementation of a next generation system-of-systems Risk Governance Framework for nanomaterials
Acronym:caLIBRAte

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License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.

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