| Title: | Significance of nuclear factor - kappa beta activation on prostate needle biopsy samples in the evaluation of Gleason score 6 prostatic carcinoma indolence |
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| Authors: | ID Zupančič, Marko (Author)
ID Pospihalj, Boris (Author)
ID Cerović, Snežana (Author)
ID Gazić, Barbara (Author)
ID Drev, Primož (Author)
ID Hočevar, Marko (Author)
ID Perhavec, Andraž (Author) |
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| Files: |  URL - Source URL, visit https://content.sciendo.com/view/journals/raon/54/2/article-p194.xml
 PDF - Presentation file, download (399,54 KB)
MD5: 813AAD70A49A965974C09E368D16CC77
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  OI - Institute of Oncology
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| Abstract: | The goal of our study was to find out whether the immunohistochemical expression of nuclear factor-kappa beta (NF-%B) p65 in biopsy samples with Gleason score 3 + 3 = 6 (GS 6) can be a negative predictive factor for Prostate cancer (PCa) indolence. Patients and methods Study was conducted on a retrospective cohort of 123 PCa patients with initial total PSA % 10 ng/ml, number of needle biopsy specimens % 8, GS 6 on biopsy and T1/T2 estimated clinical stage who underwent laparoscopic radical prostatectomy and whose archived formalin-fixed and paraffin-embedded (FFPE) prostate needle biopsy specimens were used for additional immunohistochemistry staining for detection of NF-%B p65. Both cytoplasmic and nuclear NF-%B p65 expression in biopsy cores with PCa were correlated with postoperative pathological stage, positive surgical margins, GS and biochemical progression of disease. Results After follow-up of 66 months, biochemical progression (PSA % 0.2 ng/ml) occurred in 6 (5.1%) patients, 3 (50%) with GS 6 and 3 (50%) with GS 7 after radical prostatectomy. Both cytoplasmic and nuclear NF-%B p65 expressions were not significantly associated with pathological stage, positive surgical margin and postoperative GS. Patients with positive cytoplasmic NF-kB reaction had significantly more frequent biochemical progression than those with negative cytoplasmic NF-kB reaction with PSA 0.2 ng/ml as cutoff point (p = 0.015) and a trend towards more biochemical progression with PSA % 0.05 ng/ml as cutoff point (p = 0.068). Conclusions Cytoplasmic expression of NF-%B is associated with more biochemical progression and might be an independent prognostic factor for recurrence-free survival (RFS), but further studies including larger patient cohorts are needed to confirm these initial results. |
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| Keywords: | prostate cancer, needle biopsy, nuclear factor-kappa beta, Gleason |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 01.06.2020 |
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| Publisher: | Association of Radiology and Oncology |
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| Year of publishing: | 2020 |
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| Number of pages: | str. 194-200, VII |
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| Numbering: | Vol. 54, no. 2 |
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| Source: | Ljubljana |
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| PID: | 20.500.12556/DiRROS-19281  |
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| UDC: | 616.6 |
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| ISSN on article: | 1318-2099 |
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| DOI: | 10.2478/raon-2020-0019 |
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| COBISS.SI-ID: | 13549827 |
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| Copyright: | by Authors |
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| Publication date in DiRROS: | 12.07.2024 |
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| Views: | 299 |
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| Downloads: | 157 |
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