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Title:Locoregional disease control after external beam radiotherapy in 91 patients with differentiated thyroid carcinoma and pT4 tumor stage : a single institution experience
Authors:ID Bešić, Nikola (Author)
ID Dremelj, Marta (Author)
ID Pilko, Gašper (Author)
Files:.pdf PDF - Presentation file, download (300,30 KB)
MD5: F5C7D482152A290B74D1D74B090CFB54
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo OI - Institute of Oncology
Abstract:Locoregional recurrence is common in patients with locally advanced differentiated thyroid carcinoma (DTC). Our aim was to find out the rate of locoregional control of the disease after external beam radiotherapy (EBRT) of the neck and mediastinum in patients with DTC and pT4 tumor. Patients and methods Altogether 91 patients (47 males, 44 females, median age 61 years) with DTC had EBRT of the neck and mediastinum as part of the multimodal treatment of pT4 tumor (63 cases pT4a, 28 cases pT4b) from the year 1973 to 2015. Data on clinical factors, histopathology and recurrence were collected. Disease-free, disease-specific and overall survival was calculated. Results Median tumor size was 5 cm (range 1%30 cm). Out of 91 patients, 23 had distant and 38 regional metastases. A total or near-total thyroidectomy, lobectomy, subtotal thyroidectomy and lymph node dissection was performed in 70%, 14%, 2% and 30% of cases, respectively. Thirteen percent of patients were not treated with surgery. All patients had EBRT and 39 had chemotherapy. Radioiodine (RAI) ablation of thyroid remnant and RAI therapy was applied in 90% and 40% of cases, respectively. Recurrence was diagnosed in 29/64 patients without a persistent disease: locoregional and distant in 16 and 13 cases, respectively. Five-year and ten-year disease-free survival rate was 64% and 48%, respectively. Conclusions The majority of patients with DTC and pT4 tumors who were treated with EBRT of the neck and mediastinum region as part of multimodal treatment have long-lasting locoregional control of the disease.
Keywords:thyroid carcinoma, radiotherapy, survival, pathology
Publication status:Published
Publication version:Version of Record
Publication date:01.12.2018
Publisher:Association of Radiology and Oncology
Year of publishing:2018
Number of pages:str. 453-460, VII
Numbering:Vol. 52, no. 4
Source:Ljubljana
PID:20.500.12556/DiRROS-19086 New window
UDC:616.4
ISSN on article:1318-2099
DOI:10.2478/raon-2018-0038 New window
COBISS.SI-ID:3138427 New window
Copyright:by Authors
Publication date in DiRROS:11.06.2024
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Downloads:20
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 New window

Secondary language

Language:Slovenian
Keywords:rak ščitnice, radioterapija, preživetje, patologija


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