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Title:Leiomyosarcoma of the renal vein : analysis of outcome and prognostic factors in the world case series of 67 patients
Authors:ID Novak, Marko (Author)
ID Perhavec, Andraž (Author)
ID Maturen, Katherine E. (Author)
ID Pavlović Djokić, Snežana (Author)
ID Jereb, Simona (Author)
ID Eržen, Darja (Author)
Files:URL URL - Source URL, visit https://www.degruyter.com/view/j/raon.2017.51.issue-1/raon-2016-0051/raon-2016-0051.xml?format=INT
 
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MD5: 643C4375A97802E94A18CC59C0B890BB
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo OI - Institute of Oncology
Abstract:Background Leiomyosarcoma is a rare malignant mesenchymal tumour. Some cases of leiomyosarcoma of the renal vein (LRV) have been reported in the literature, but no analysis of data and search for prognostic factors have been done so far. The aim of this review was to describe the LRV, to analyse overall survival (OS), local recurrence free survival (LRFS) and distant metastases free survival (DMFS) in LRV world case series and to identify significant predictors of OS, LRFS and DMFS. Methods Cases from the literature based on PubMed search and a case from our institution were included. Results Sixty-seven patients with a mean age of 56.6 years were identified; 76.1% were women. Mean tumour size was 8.9 cm; in 68.7% located on the left side. Tumour thrombus extended into the inferior vena cava lumen in 13.4%. All patients but one underwent surgery (98.5%). After a median follow up of 24 months, the OS was 79.5%. LRFS was 83.5% after a median follow up of 21.5 months and DMFS was 76.1% after a median follow up of 22 months. Factors predictive of OS in univariate analysis were surgical margins, while factors predictive of LRFS were inferior vena cava luminal extension and grade. No factors predictive of DMFS were identified. In multivariate analysis none of the factors were predictive of OS, LRFS and DMFS. Conclusions Based on the literature review and presented case some conclusions can be made. LRV is usually located in the hilum of the kidney. It should be considered in differential diagnosis of renal and retroperitoneal masses, particularly in women over the age 40, on the left side and in the absence of haematuria. Core needle biopsy should be performed. Patients should be managed by sarcoma multidisciplinary team. LRV should be surgically removed, with negative margins.
Keywords:leiomysarcoma, renal vein, surgery, outcomes, prognostic factors
Publication status:Published
Publication version:Version of Record
Publication date:01.03.2017
Publisher:Association of Radiology and Oncology
Year of publishing:2017
Number of pages:str. 56-64, V
Numbering:Vol. 51, no. 1
Source:Ljubljana
PID:20.500.12556/DiRROS-19004 New window
UDC:616-006
ISSN on article:1318-2099
DOI:10.1515/raon-2016-0051 New window
COBISS.SI-ID:2634619 New window
Copyright:by Authors
Publication date in DiRROS:24.05.2024
Views:162
Downloads:146
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 New window

Secondary language

Language:Slovenian
Keywords:lemiosarkom, ledvična vena, kirurgija, preživetje, napovedni dejavniki


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