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Title:Compensational role between cathepsins
Authors:ID Pečar Fonović, Urša (Author)
ID Kos, Janko, Institut Jožef Stefan (Author)
ID Mitrović, Ana, Institut Jožef Stefan (Author)
Files:URL URL - Source URL, visit https://www.sciencedirect.com/science/article/pii/S0300908424000853?via%3Dihub
 
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MD5: AA95D8DD6EC3EBC07FD8DFA8B78AA5FC
 
Language:English
Typology:1.02 - Review Article
Organization:Logo IJS - Jožef Stefan Institute
Abstract:Cathepsins, a family of lysosomal peptidases, play a crucial role in maintaining cellular homeostasis by regulating protein turnover and degradation as well as many specific regulatory actions that are important for proper cell function and human health. Alterations in the activity and expression of cathepsins have been observed in many diseases such as cancer, inflammation, neurodegenerative disorders, bone remodelling-related conditions and others. These changes are not exclusively harmful, but rather appear to be a compensatory response on the lack of one cathepsin in order to maintain tissue integrity. The upregulation of specific cathepsins in response to the inhibition or dysfunction of other cathepsins suggests a fine-tuned system of proteolytic balance and understanding the compensatory role of cathepsins may improve therapeutic potential of cathepsin's inhibitors. Selectively targeting one cathepsin or modulating their activity could offer new treatment strategies for a number of diseases. This review emphasises the need for comprehensive research into cathepsin biology in the context of disease. The identification of the specific cathepsins involved in compensatory responses, the elucidation of the underlying molecular mechanisms and the development of targeted interventions could lead to innovative therapeutic approaches.
Keywords:lysosomal peptidases, compensation, bone resorption
Publication status:In print
Publication version:Author Accepted Manuscript
Submitted for review:03.04.2024
Article acceptance date:22.04.2024
Publisher:Elsevier
Year of publishing:2024
Number of pages:str. 1-51
Numbering:Vol. , [article no.]
Source:Nizozemska
PID:20.500.12556/DiRROS-18979 New window
UDC:577
ISSN on article:1638-6183
DOI:10.1016/j.biochi.2024.04.010 New window
COBISS.SI-ID:193579011 New window
Copyright:©2024TheAuthors.
Note:Nasl. z nasl. zaslona; Opis vira z dne 23. 4. 2024;
Publication date in DiRROS:23.05.2024
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Downloads:87
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Record is a part of a journal

Title:Biochimie
Shortened title:Biochimie
Publisher:Ed. scientifiques et médicales Elsevier
ISSN:1638-6183
COBISS.SI-ID:193576195 New window

Document is financed by a project

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:J3-3071
Name:Katepsina B in X v tumorskih matičnih celicah raka dojke – molekulske tarče in pomen za protitumorno terapijo

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:P4-0127
Name:Farmacevtska biotehnologija: znanost za zdravje

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License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.

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