| Title: | Compensational role between cathepsins |
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| Authors: | ID Pečar Fonović, Urša (Author)
ID Kos, Janko, Institut Jožef Stefan (Author)
ID Mitrović, Ana, Institut Jožef Stefan (Author) |
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| Files: |  URL - Source URL, visit https://www.sciencedirect.com/science/article/pii/S0300908424000853?via%3Dihub
 PDF - Presentation file, download (730,45 KB)
MD5: AA95D8DD6EC3EBC07FD8DFA8B78AA5FC
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| Language: | English |
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| Typology: | 1.02 - Review Article |
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| Organization: |  IJS - Jožef Stefan Institute
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| Abstract: | Cathepsins, a family of lysosomal peptidases, play a crucial role in maintaining cellular homeostasis by regulating protein turnover and degradation as well as many specific regulatory actions that are important for proper cell function and human health. Alterations in the activity and expression of cathepsins have been observed in many diseases such as cancer, inflammation, neurodegenerative disorders, bone remodelling-related conditions and others. These changes are not exclusively harmful, but rather appear to be a compensatory response on the lack of one cathepsin in order to maintain tissue integrity. The upregulation of specific cathepsins in response to the inhibition or dysfunction of other cathepsins suggests a fine-tuned system of proteolytic balance and understanding the compensatory role of cathepsins may improve therapeutic potential of cathepsin's inhibitors. Selectively targeting one cathepsin or modulating their activity could offer new treatment strategies for a number of diseases. This review emphasises the need for comprehensive research into cathepsin biology in the context of disease. The identification of the specific cathepsins involved in compensatory responses, the elucidation of the underlying molecular mechanisms and the development of targeted interventions could lead to innovative therapeutic approaches. |
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| Keywords: | lysosomal peptidases, compensation, bone resorption |
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| Publication status: | In print |
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| Publication version: | Author Accepted Manuscript |
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| Submitted for review: | 03.04.2024 |
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| Article acceptance date: | 22.04.2024 |
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| Publisher: | Elsevier |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 1-51 |
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| Numbering: | Vol. , [article no.] |
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| Source: | Nizozemska |
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| PID: | 20.500.12556/DiRROS-18979  |
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| UDC: | 577 |
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| ISSN on article: | 1638-6183 |
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| DOI: | 10.1016/j.biochi.2024.04.010 |
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| COBISS.SI-ID: | 193579011 |
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| Copyright: | ©2024TheAuthors. |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 23. 4. 2024;
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| Publication date in DiRROS: | 23.05.2024 |
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| Views: | 409 |
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| Downloads: | 274 |
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| Metadata: |    |
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