| Title: | CA19-9 serum levels predict micrometastases in patients with gastric cancer |
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| Authors: | ID Jagrič, Tomaž (Author)
ID Potrč, Stojan (Author)
ID Miš, Katarina (Author)
ID Plankl, Mojca (Author)
ID Marš, Tomaž (Author) |
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| Files: |  URL - Source URL, visit http://ojs.szd.si/index.php/ro/article/view/2257/1872
 PDF - Presentation file, download (793,76 KB)
MD5: 7C8AAB04CB52B9FAE01DE7B978E682B6
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  OI - Institute of Oncology
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| Abstract: | Background. We explored the prognostic value of the up-regulated carbohydrate antigen (CA19-9) in node-negative patients with gastric cancer as a surrogate marker for micrometastases. Patients and methods. Micrometastases were determined using reverse transcription quantitative polymerase chain reaction (RT-qPCR) for a subgroup of 30 node-negative patients. This group was used to determine the cut-off for preoperative CA19-9 serum levels as a surrogate marker for micrometastases. Then 187 node-negative T1 to T4 patients were selected to validate the predictive value of this CA19-9 threshold. Results. Patients with micrometastases had significantly higher preoperative CA19-9 serum levels compared to patients without micrometastases (p = 0.046). CA19-9 serum levels were significantly correlated with tumour site, tumour diameter, and perineural invasion. Although not reaching significance, subgroup analysis showed better five-year survival rates for patients with CA19-9 serum levels below the threshold, compared to patients with CA19-9 serum levels above the cut-off. The cumulative survival for T2 to T4 node-negative patients was significantly better with CA19-9 serum levels below the cut-off (p = 0.04). Conclusions. Preoperative CA19-9 serum levels can be used to predict higher risk for haematogenous spread and micrometastases in node-negative patients. However, CA19-9 serum levels lack the necessary sensitivity and specificity to reliably predict micrometastases. |
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| Keywords: | gastric cancer, micrometastases, CA19-9, rak (medicina), želodec, metastaze, diagnostika, antigeni, tumorski označevalci |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 01.06.2016 |
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| Publisher: | Association of Radiology and Oncology |
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| Year of publishing: | 2016 |
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| Number of pages: | str. 204-211, VI |
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| Numbering: | Vol. 50, no. 2 |
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| Source: | Ljubljana |
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| PID: | 20.500.12556/DiRROS-18890  |
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| UDC: | 616.3-006-07 |
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| ISSN on article: | 1318-2099 |
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| DOI: | 10.1515/raon-2015-0025 |
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| COBISS.SI-ID: | 5741375 |
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| Copyright: | by Authors |
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| Note: | Soavtorji: Stojan Potrc, Katarina Mis, Mojca Plankl, Tomaz Mars;
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| Publication date in DiRROS: | 09.05.2024 |
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| Views: | 1109 |
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| Downloads: | 683 |
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