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Title:Granulomatosis after autologous stem cell transplantation in nonHodgkin lymphoma : experience of single institution and a review of literature
Authors:ID Boltežar, Lučka (Author)
ID Žagar, Ivana (Author)
ID Jezeršek Novaković, Barbara (Author)
Files:.pdf PDF - Presentation file, download (687,65 KB)
MD5: 021591EFA48B1007C989D2B253B65E65
 
Language:English
Typology:1.02 - Review Article
Organization:Logo OI - Institute of Oncology
Abstract:Sarcoidosis before and after treatment of malignancy is an important differential diagnosis that has to be distinguished from lymphoma. Patients and methods. Hodgkin lymphoma, diffuse large B-cell lymphoma and aggressive follicular lymphoma are being staged and treatment effect is evaluated with PET-CT. We report three cases of aggressive lymphoma after high dose therapy and autologous stem cell transplantation with positive lymph nodes on PET-CT, which were histologically diagnosed as sarcoidosis/granulomatosis. In the literature, we found that false positive lymph nodes were more common after allogeneic than after autologous transplantation. Conclusions. Post-treatment PET-CT positive lymph nodes should always be examined histologically prior to any further treatment decision to avoid unnecessary toxic procedures.
Keywords:granulomatosis, nonHodgin lymphoma, PET-CT, differential diagnosis
Publication status:Published
Publication version:Version of Record
Publication date:01.12.2016
Publisher:Association of Radiology and Oncology
Year of publishing:2016
Number of pages:str. 355-359, I
Numbering:Vol. 50, no. 4
Source:Ljubljana
PID:20.500.12556/DiRROS-18851 New window
UDC:616-006
ISSN on article:1318-2099
DOI:10.1515/raon-2015-0033 New window
COBISS.SI-ID:2058619 New window
Copyright:by Authors
Publication date in DiRROS:30.04.2024
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Downloads:140
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 New window

Secondary language

Language:Slovenian
Abstract:Sarkoidoza pred in po zdravljenju raka je pomembna diferencialna diagnoza, ki jo je potrebno razlikovati od limfoma. Bolniki in metode. Za oceno razširjenosti bolezni in učinkovitosti zdravljenja v skladu z novimi priporočili pri Hodgkinovem limfomu, difuznem velikoceličnem B limfomu in agresivnem folikularnem limfomu uporabljamo PET-CT. V članku opisujemo tri primere suma na ponovitev agresivnega limfoma (metabolno aktivne bezgavke na PET-CT) po visokodoznem zdravljenju in avtologni presaditvi krvotvornih matičnih celic. Pri vseh treh bolnikih smo histološko diagnosticirali sarkoidozo/ granulomatozo. V literaturi smo zasledili, da so lažno pozitivne bezgavke pogostejše po alogenični kot pa po avtologni presaditvi matičnih celic. Zaključki. Na PET-CT ugotovljene metabolno aktivne bezgavke po zdravljenju limfoma je potrebno vedno histološko opredeliti pred kakršno koli odločitvijo o nadaljnjem zdravljenju. Tako se izognemo morebitnim nepotrebnim postopkom, ki imajo lahko hude neželene učinke.
Keywords:granulomatoza, neHodginov limfom, diferencialna diagnoza


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