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Title:Neoadjuvant chemotherapy in 13 patients with locally advanced poorly differentiated thyroid carcinoma based on Turin proposal : a single institution experience
Authors:ID Bešić, Nikola (Author)
ID Dremelj, Marta (Author)
ID Schwarzbartl-Pevec, Andreja A. (Author)
ID Gazić, Barbara (Author)
Files:.pdf PDF - Presentation file, download (459,46 KB)
MD5: 01FC3E9A3DEF9521E783FA0F03210CA4
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo OI - Institute of Oncology
Abstract:There is a paradigm that chemotherapy is ineffective in thyroid carcinoma. The aim of our study was to find out whether neoadjuvant chemotherapy before thyroid surgery had an effect on the size of primary tumour in patients with poorly differentiated thyroid carcinoma (PDTC) based on Turin proposal. Patients and methods. Altogether, 13 patients (8 women, 5 men; median age 61 years) with PDTC based on Turin proposal were treated with neoadjuvant chemotherapy between 1986 and 2005. Tumour diameter was from 4.5 to 18 cm (median 9 cm). Regional and distant metastases were detected in 6 and 9 patients, respectively. Eight patients had pT4 tumour. Results. Altogether, 29 (range 1%5) cycles of chemotherapy were given. Tumour diameter decreased in all the patients and by more than 30% in 5 patients (= 38%). Two of these five patients had also preoperative external beam irradiation (EBRT). Total thyroidectomy, lobectomy and neck dissection were performed in 10, 3 and 5 cases, respectively. R0 and R1 resection was done in 5 and 8 cases, respectively. Eight patients had postoperative EBRT of the neck and upper mediastinum. The 5-year and 10-year cause-specific survival rates of patients were 66% and 20%, respectively. Conclusions. After neoadjuvant chemotherapy a partial tumour regression was observed in 38% of patients with PDTC based on Turin proposal.
Keywords:poorly differentiated thyroid carcinoma, neoadjuvant, chemotherapy, survival
Publication status:Published
Publication version:Version of Record
Publication date:01.09.2015
Publisher:Association of Radiology and Oncology
Year of publishing:2015
Number of pages:str. 271-278, V
Numbering:Vol 49, no. 3
Source:Ljubljana
PID:20.500.12556/DiRROS-18788 New window
UDC:616.4
ISSN on article:1318-2099
DOI:10.1515/raon-2015-0001 New window
COBISS.SI-ID:2077051 New window
Copyright:by Authors
Publication date in DiRROS:22.04.2024
Views:537
Downloads:387
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 New window

Secondary language

Language:Slovenian
Keywords:slabo diferencirani rak ščitnice, neoadjuvantno zdravljenje, kemoterapija, preživetje


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