| Title: | Circulating serum sVCAM-1 concentration inadvanced ovarian cancer patients : correlation with concentration in ascites |
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| Authors: | ID Jakimovska, Marina (Author)
ID Černe, Katarina (Author)
ID Verdenik, Ivan (Author)
ID Kobal, Borut (Author) |
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| Files: |  PDF - Presentation file, download (491,78 KB)
MD5: 34DAC18AFF6DBF49699FB6A30D44987B
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  OI - Institute of Oncology
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| Abstract: | Background. Vascular cell adhesion molecule-1 (VCAM-1) is associated with ovarian cancer progression but theorigin of its soluble form (sVCAM-1) in serum is not well investigated. The purpose of this study was to elucidate whetherthe concentration of sVCAM-1 in serum correlates with the concentration in ascites, that represents local tumour environment,and with systemic inflammation, various clinicopathological characteristics, and patient outcome.Patients and methods. Thirty-six patients with advanced ovarian cancer were included in the study. Serum forsVCAM-1 analysis was obtained prior to surgery. Ascites samples were collected at the beginning of the operation.Clinical data were collected from patients medical records. sVCAM-1 in samples was analysed by flow cytometricbead-based assay. The mean follow-up period was 11 months (range 0-23) from the time of surgery.Results. Serum sVCAM-1 concentrations are positively correlated to ascites sVCAM-1 concentrations. There was aweakly positive correlation of serum sVCAM-1 with tumour size and no correlation with inflammatory tumour markers,FIGO stage or grade. Higher concentrations of sVCAM-1 were associated with poor disease outcome (death fromovarian cancer) in almost all cases before chemotherapy was started.Conclusion. This is the first study demonstrating that serum concentrations of sVCAM-1 in advanced ovarian cancerpatients correlate with sVCAM-1 concentrations in ascites, thus expressing the biologic potential of malignant diseaseto metastasis, rather than systemic inflammation. Higher serum and ascites sVCAM-1 concentrations might have predictivepotential for different biologic behaviour. |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 01.09.2014 |
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| Publisher: | Association of Radiology and Oncology |
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| Year of publishing: | 2014 |
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| Number of pages: | str. 307-313, VI |
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| Numbering: | Vol. 48, iss. 3 |
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| Source: | Ljubljana |
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| PID: | 20.500.12556/DiRROS-18691  |
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| UDC: | 616-006 |
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| ISSN on article: | 1318-2099 |
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| DOI: | 10.2478/raon-2013-0066 |
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| COBISS.SI-ID: | 30924505 |
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| Copyright: | by Authors |
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| Note: | Soavtorji: Katarina Cerne, Ivan Verdenik, Borut Kobal;
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| Publication date in DiRROS: | 16.04.2024 |
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| Views: | 713 |
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| Downloads: | 328 |
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