| Title: | Cysteine proteinase inhibitors stefin A and stefin B in operable carcinoma of the head and neck : Inhibitorji cisteinskih proteinaz stefin A in stefin B pri operabilnem karcinomu glave in vratu |
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| Authors: | ID Strojan, Primož (Author)
ID Budihna, Marjan (Author)
ID Šmid, Alojz (Author)
ID Svetic, Branka (Author)
ID Vrhovec, Ivan (Author)
ID Kos, Janko (Author)
ID Škrk, Janez (Author) |
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| Files: |  PDF - Presentation file, download (114,91 KB)
MD5: D98F9D4181AC08ADDD881B3EBDB2916F
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  OI - Institute of Oncology
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| Abstract: | Purpose. To evaluate the significance of cysteine proteinase inhibitors stefins (Stefs) A and B for a treatment decision and prognosis in operable squamous cell carcinoma of the head and neck (SCCHN). Patients and methods. Stefs A and B concentrations were determined immunobiochemically using ELISAs in cytosols prepared from the tumor and adjacent normal mucosa from 91 patients with operable SCCHN. The median follow-up period of patients alive atthe close-out date was 5.8 years (range, 5-9.3 years). Results. Stef A concentrations were significantly higher in tumor compared to normal mucosa (FM.05). When a subgroup with clinically palpable nodes) at presentation was taken into consideration (n=57), a significant difference in Stef A (P=0.03) and Stef B (P=0.02) concentrations between those with negative and positive necks, as determined on histopathological examination, was observed. On the univariate survival analysis, higher Stefsć concentrations turned to be prognostically advantageous. Stef A proved its independent prognostic significance also on multivariate setting. Conclusions. With the capability todifferentiate between the pN0- and pN+-stages of the disease in the patientsoriginally presented as node-positive, Stefs A and B could be useful markers when deciding on the extent of neck surgery. In addition, both Stefs proved to be reliable prognosticators for survival in patients with operable SCCHN. |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 01.01.2002 |
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| Publisher: | Slovenian Medical Association - Slovenian Association of Radiology, Nuclear Medicine Society, Slovenian Society far Radiotherapy and Oncology, and Slovenian Cancer Society |
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| Year of publishing: | 2002 |
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| Number of pages: | str. 145-151 |
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| Numbering: | Vol. 36, no. 2 |
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| Source: | Ljubljana |
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| PID: | 20.500.12556/DiRROS-18063  |
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| UDC: | 577 |
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| ISSN on article: | 1318-2099 |
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| COBISS.SI-ID: | 16895783 |
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| Copyright: | by Authors |
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| Publication date in DiRROS: | 31.01.2024 |
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| Views: | 1168 |
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| Downloads: | 299 |
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