Title: | Cathepsin D and plasminogen activator inhibitor type 1 in normal, benign and alignant ovarian tissues : a preliminary report |
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Authors: | ID Šprem, Marina (Author) ID Babić, Damir (Author) ID Abramić, Marija (Author) ID Miličić, Duško (Author) ID Vrhovec, Ivan (Author) ID Škrk, Janez (Author) ID Osmak, Maja (Author) |
Files: | PDF - Presentation file, download (442,49 KB) MD5: 1C6BCCFA14ADF6A5E13A441CC7CB3C8B
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Language: | English |
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Typology: | 1.01 - Original Scientific Article |
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Organization: | OI - Institute of Oncology
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Abstract: | Background. The aim of the present study was to determine the concentration ofcathepsin D (Cath D) and plasminogen activator inhibitor type 1 (PAI-1) in normal ovarian tissues, benign and malignant ovarian tumor tissues, and to asses relationship between Cath D and PAI-1 content, and some clinical and pathohistological parameters. Materials and methods. Cath D contents and PAI-1concentrations were determined (using immunoradiometric ELSA-Cath D assayand commercial IMUDIND R ELISA immunoassay, respectively) in 35 samples: 10 normal ovarii, 10 benign, 10 primary malignant and 5 metastatic ovarian tumors. Results. The concentrations of Cath D were significantly higher in malignant (32.89+-14.26 pmol/mg protein ) and metastatic (31.42+-10.24 pmol/mgprotein), than in normal (13.68+-4.03 pmol/mg protein) and benign (17.89+-13.13 pmol/mg protein) ovarian tissues. There was no statistical differences in the concentrations of PAI-1 between normal, benign, malignant and metastatic tumor specimens. The concentrations of Cath D as well as PAI-1 did not correlate to the age of patients, menopausal status, parity, GOG risk group, clinical stage or pathohistological grading. Conclusion. Concentrationsof Cath D (but not PAI-1) were significantly increased in malignant and metastatic ovarian tumor tissues when compared to normal and benign ovarian tumor samples; they were independent from pathohistological andclinical parameters. |
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Publication status: | Published |
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Publication version: | Version of Record |
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Publication date: | 01.03.2000 |
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Publisher: | Slovenian Medical Association - Slovenian Association of Radiology, Nuclear Medicine Society, Slovenian Society far Radiotherapy and Oncology, and Slovenian Cancer Society |
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Year of publishing: | 2000 |
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Number of pages: | str. 41-47 |
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Numbering: | Letn. 34, št. 1 |
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Source: | Ljubljana |
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PID: | 20.500.12556/DiRROS-17940 ![Link is opened in a new window New window](teme/dirros/img/NovoOkno.png) |
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UDC: | 616-006 |
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ISSN on article: | 1318-2099 |
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COBISS.SI-ID: | 11320281 ![Link is opened in a new window New window](teme/dirros/img/NovoOkno.png) |
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Copyright: | by Authors |
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Note: | BSDOCID51340;
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Publication date in DiRROS: | 23.01.2024 |
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Views: | 358 |
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Downloads: | 103 |
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Metadata: | ![Export as DC-RDF DC-RDF](teme/dirros/img/icon_dc_rdf.gif) |
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