| Title: | Cryosurgery combined with radiotherapy of tumors in mice |
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| Authors: | ID Fras, Albert-Peter (Author)
ID Kranjc Brezar, Simona (Author)
ID Čemažar, Maja (Author)
ID Serša, Gregor (Author) |
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| Files: |  PDF - Presentation file, download (311,91 KB)
MD5: A41DFC91E2F6196E142084DE332CA1C1
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  OI - Institute of Oncology
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| Abstract: | Tlle aim of this study zuas to determine antitumor effectiveness of cryosurgery alone and in comhination with radiotherapy. Cryosurgery of subcutaneous fibrosarcoma SA-1 tumors in A/J mice was moderately effective trcatmcnt. Tumor growth delay was 10.3 * 3.8 days after 5 minute treatment with nitrogen filled cryo-prohe. Shorter treatment times induced less, but dose dependent antitumor effect. In combined treat- ment, tumors were either first treated by cryosurgery for 3 minutes and then locally irradiated with 10Gy for 5 minutes, or irradiated first and thereafter treated by cryosurgery.The antitumor effectiveness of com- bined treatrnent was sequence dependent; the irradiation of tumors before cryosurgery resulted in better antitumor effect than the irradiation after cryosurgery. These results indicate that radiosensitization may not be always expected, in spite of some reports demonstrating that cryosurgery may have radiosensitizing effect in vivo, and that some other mechanisms may be involved contributing to radiationdamage when cryosurgery follows irradiation. |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 01.01.1999 |
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| Publisher: | Slovenian Medical Association - Slovenian Association of Radiology, Nuclear Medicine Society, Slovenian Society far Radiotherapy and Oncology, and Slovenian Cancer Society |
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| Year of publishing: | 1999 |
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| Number of pages: | str. 221-225 |
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| Numbering: | Letn. 33, št. 3 |
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| Source: | Ljubljana |
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| PID: | 20.500.12556/DiRROS-17920  |
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| UDC: | 616-006 |
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| ISSN on article: | 1318-2099 |
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| COBISS.SI-ID: | 10783961 |
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| Copyright: | by Authors |
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| Note: | BSDOCID46575;
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| Publication date in DiRROS: | 22.01.2024 |
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| Views: | 532 |
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| Downloads: | 137 |
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| Metadata: |    |
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