| Title: | Plasma membrane fluidity alterations in cancerous tissues |
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| Authors: | ID Šentjurc, Marjeta (Author)
ID Sok, Mihael (Author)
ID Serša, Gregor (Author) |
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| Files: |  PDF - Presentation file, download (1,91 MB)
MD5: 0C70FFBD3D79E0804EAF0578A84B8700
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  OI - Institute of Oncology
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| Abstract: | Plasma membrane is a heterogeneous structure with several coexisting domains having different fluidity characteristics. It plays an important role in the control of cell growth, differentiation and transformation. Fluidity of the whole plasma membrane reflects the ordering and dynamics of phospholipid acyl chains in specific membrane domains, as well as the fraction of each domain inthe membrane. Changes in the membrane fluidity affect processes on the membrane such as transport, enzyme activities and expression of the redeptors.In this paper we present results of our recent electron paramagneticresonance (EPR) studies of plasma membrane fluidity characteristics, which take into account heterogeneous nature of the plasma membrane, By the computer simulation of the EPR spectra line-shapes, the number of coexisting domains in the plasma membrane, their relative portion inthe membrane as well as the ordering and dynamics of each domain be determined. Therefore, we could distinguish the contribution of the relative portion of each domain from the contribution of fulidity alterations in the domain to the entire fluidity changes in the membrane. Two examples will be discussed: membrane fluidity characteristics of excised lung tumor tissues andinfluence of microtubule depolymerizing agent vinblastine on membrane fluidity of vinblastine sensitive and resistant HeLa cells. |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 01.01.1998 |
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| Publisher: | Slovenian Medical Society - Section of Radiology ; Croatian Medical Association - Croatian Society of Radiology |
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| Year of publishing: | 1998 |
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| Number of pages: | str. 109-117 |
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| Numbering: | Letn. 32, št. 1 |
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| Source: | Ljubljana |
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| PID: | 20.500.12556/DiRROS-17892  |
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| UDC: | 616-006 |
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| ISSN on article: | 1318-2099 |
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| COBISS.SI-ID: | 7824345 |
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| Copyright: | by Authors |
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| Note: | Life sciences '97 and 2nd Slovenian-Croatian meeting on Molecular oncology today; 1997 Oct 16-19; Gozd Martuljek;
BSDOCID37117;
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| Publication date in DiRROS: | 19.01.2024 |
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| Views: | 533 |
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| Downloads: | 145 |
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| Metadata: |    |
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