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Title:Fotokarcinogeneza
Authors:ID Kansky, Aleksej (Author)
Files:.pdf PDF - Presentation file, download (410,62 KB)
MD5: 4BA8C67C9DD477923BE58B1B17EBADC7
 
Language:Slovenian
Typology:1.02 - Review Article
Organization:Logo OI - Institute of Oncology
Abstract:Fotokarcinogeneza je zapleten in kompleksen proces. Epidemiološke študije in poskusi na živalih kažejo, da je najpomembnejši činitelj ultravijolična (UV) svetloba z valovno dolžino med 320 in 280 nm. UV žarki lahko okvarjajo neposredno molekule deoksiribonukleinske kisline (DNK) v jedrih celic, pomembnejša pa je aktivacija različnih molekul, ki prehajajo v ekscitirano stanje ter se nato spojijo z DNK v fotoadukte. Ekscitirano stanje traja le delce sekunde, ko preneha, se sproščajo različne oblike energije, pri čemer prihaja do okvare celic in njihovih organel, kakor tudi do nastanka različnih škodljivih spojin kot so npr. peroksidi. Za nastanek kožnih karcinomov so pomembni še nekateri drugi procesi: moteno delovanje reparacijskih encimov, imunosupresijski učinek UV svetlobe na limfocite T, akkor tudi aktivnost onkogenov in antionkogenov. Pri vseh naštetih procesih sodeluje tudi dednost, saj vpliva med drugim na občutlivost kože za svetlobo, na reparacijske encime,na občutljivost limfocitov na svetlobo ter na delovanje onkogenov.
Publication status:Published
Publication version:Version of Record
Publication date:01.01.1999
Publisher:Slovenian Medical Association - Slovenian Association of Radiology, Nuclear Medicine Society, Slovenian Society far Radiotherapy and Oncology, and Slovenian Cancer Society
Year of publishing:1999
Number of pages:str. S69-74
Numbering:Letn. 33, suppl. 1
Source:Ljubljana
PID:20.500.12556/DiRROS-17373 New window
UDC:616-006
ISSN on article:1318-2099
COBISS.SI-ID:10734553 New window
Copyright:by Authors
Note:Simpozij o malignem melanomu in kožnem raku; BSDOCID48319;
Publication date in DiRROS:28.11.2023
Views:327
Downloads:78
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Record is a part of a journal

Title:Radiology and oncology
Shortened title:Radiol. oncol.
Publisher:Slovenian Medical Society - Section of Radiology, Croatian Medical Association - Croatian Society of Radiology
ISSN:1318-2099
COBISS.SI-ID:32649472 New window

Secondary language

Language:English
Title:Photocarcinogenesis
Abstract:Photocarcinogenesis is a complex and still not fully explored process. Epidemiological studies as well as animal experiments show that wave lenghts in the range of 320-280 nm (UV B) are the main pathogenetic factor. Skin complexion and other genetic factors are however also important. The UV B raysare injuring directly the molecules of deoxyribonucleic acidic in the nuclei keratinocytes, fibroblast and Langerhans; cells, but the inducement of various molecules (chromatophores) into an excited stage is a further pathogenetic mechanism. This situation lasts only fraction of a ssecond and the relase of various forms of energy, which follows, is injuring cells and their organel as well as producing noxious products, e.g., pereoxides. In the inducement of carcinogenesis further mechanisms are usually coivolved as an impaired action of repartion enzmes, immunosuppression of T lymphocytes by UV B, expression of oncogenes and antiocogenes and others. A short review of th eabove mentioned processes is given.


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