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Title:Neuromuscular assessment of force development, postural, and gait performance under cognitive-motor dual-tasking in healthy older adults and early Parkinson's disease patients : study protocol for a cross-sectional Mobile Brain/Body Imaging (MoBI) study
Authors:ID Marušič, Uroš (Author)
ID Peskar, Manca (Author)
ID Šömen, Maja Maša (Author)
ID Kalc, Miloš (Author)
ID Holobar, Aleš (Author)
ID Gramann, Klaus (Author)
ID Wollesen, Bettina (Author)
ID Wunderlich, Anna (Author)
ID Michel, Christoph M. (Author)
ID Miladinović, Aleksandar (Author)
ID Catalan, Mauro (Author)
ID Stella, Alex B. (Author)
ID Ajčević, Miloš (Author)
ID Manganotti, Paolo (Author)
Files:URL URL - Source URL, visit
.pdf PDF - Presentation file, download (1,36 MB)
MD5: 30753A62D30775C107A2B8C6DF82ADC8
Typology:1.01 - Original Scientific Article
Organization:Logo ZRS Koper - Science and Research Centre Koper
Abstract:Background: Neuromuscular dysfunction is common in older adults and more pronounced in neurodegenerative diseases. In Parkinson's disease (PD), a complex set of factors often prevents the effective performance of activities of daily living that require intact and simultaneous performance of the motor and cognitive tasks. Methods: The cross-sectional study includes a multifactorial mixed-measure design. Between-subject factor grouping the sample will be Parkinson’s Disease (early PD vs. healthy). The within-subject factors will be the task complexity (single- vs. dual-task) in each motor activity, i.e., overground walking, semi-tandem stance, and isometric knee extension, and a walking condition (wide vs. narrow lane) will be implemented for the overground walking activity only. To study dual-task (DT) effects, in each motor activity participants will be given a secondary cognitive task, i.e., a visual discrimination task for the overground walking, an attention task for the semi-tandem, and mental arithmetic for the isometric extension. Analyses of DT effects and underlying neuronal correlates will focus on both gait and cognitive performance where applicable. Based on an a priori sample size calculation, a total N = 42 older adults (55-75 years) will be recruited. Disease-specific changes such as laterality in motor unit behavior and cortical control of movement will be studied with high-density surface electromyography and electroencephalography during static and dynamic motor activities, together with whole-body kinematics. Discussion: This study will be one of the first to holistically address early PD neurophysiological and neuromuscular patterns in an ecologically valid environment under cognitive-motor DT conditions of different complexities. The outcomes of the study aim to identify the biomarker for early PD either at the electrophysiological, muscular or kinematic level or in the communication between these systems.
Keywords:Parkinson's disease, mobile brain imaging, body brain imaging, MoBi, dual tasking, neuromuscular function, older adults
Publication status in journal:Published
Article version:Postprint, final article version, accepted into publication
Publication date:25.08.2023
Year of publishing:2023
Number of pages:14 str.
Numbering:Vol. 3, [article no.] ǂ58
PID:20.500.12556/DiRROS-17049 New window
ISSN on article:2732-5121
DOI:10.12688/openreseurope.15781.2 New window
COBISS.SI-ID:164659715 New window
Copyright:© 2023 Marusic U et al
Note:Nasl. z nasl. zaslona; Soavtorji: Manca Peskar, Maja Maša Šömen, Miloš Kalc, Ales Holobar, Klaus Gramann, Bettina Wollesen, Anna Wunderlich, Christoph Michel, Aleksandar Miladinović, Mauro Catalan, Alex Buoite Stella, Milos Ajcevic, Paolo Manganotti; Opis vira z dne 15. 9. 2023;
Publication date in DiRROS:15.09.2023
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Record is a part of a journal

Title:Open research Europe
Publisher:European Commission
COBISS.SI-ID:80728323 New window

Document is financed by a project

Funder:EC - European Commission
Funding programme:H2020
Project number:952401
Name:TWINning the BRAIN with machine learning for neuro-muscular efficiency

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:P5-0381
Name:Kineziologija za kakovost življenja

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:P2-0041
Name:Računalniški sistemi, metodologije in inteligentne storitve

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:J2-1731
Name:Dekompozicija sestavljenih mišičnih potencialov


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:25.08.2023

Secondary language

Keywords:mobilne telesne oslikave, možganske oslikave, dvojna naloga, živčnomišične funkcije