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Title:Effects of COVID-19 on cognition and mood after hospitalization and at 2-month follow-up
Authors:ID Peskar, Manca (Author)
ID Šimunič, Boštjan (Author)
ID Šlosar, Luka (Author)
ID Pišot, Saša (Author)
ID Teraž, Kaja (Author)
ID Gasparini, Mladen (Author)
ID Pišot, Rado (Author)
ID Marušič, Uroš (Author)
Files:URL URL - Source URL, visit https://doi.org/10.3389/fpsyg.2023.1141809
 
.pdf PDF - Presentation file, download (643,65 KB)
MD5: E1035B25A1431393DD312ACC66E64668
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo ZRS Koper - Science and Research Centre Koper
Abstract:A plethora of evidence links SARS-CoV-2 infection with concomitant cognitive dysfunction, which often persists weeks to months after the acute stages of illness and affects executive function, attention, memory, orientation, and movement control. It remains largely unclear which conditions or factors exacerbate the recovery. In a cohort of N=37 Slovenian patients (5 females, aged M = 58, SD = 10.7 years) that were hospitalized because of COVID-19, the cognitive function and mood states were assessed immediately after discharge and 2-months later to investigate the early post-COVID recovery changes. We assessed the global Montreal Cognitive Assessment (MoCA), Simple and Choice Reaction Times, executive functions (Trail-Making Test – TMT-A and TMT-B), short-term memory (Auditory Verbal Learning Test – AVLT), and visuospatial memory. We monitored depressive and anxiety symptoms and applied general self-efficacy and cognitive complaints questionnaires. Our results showed a global cognitive impairment (MoCA, Z = 332.5; p = 0.012), poorer performance on executive functions (TMT-A, Z = 188; p = 0.014; and TMT-B, Z = 185; p = 0.012), verbal memory (AVLT, F = 33.4; p < 0.001), and delayed recall (AVLT7, F = 17.1; p < 0.001), and higher depressive (Z = 145; p = 0.015) and anxiety (Z = 141; p = 0.003) symptoms after hospital discharge compared to 2-month follow-up, indicating that SARS-CoV-2 may transiently impair cognitive function and adversely affect the mood. No improvement in MoCA was observed in 40.5% of the patients at follow-up, indicating possible long-term effects of COVID-19 on global cognitive performance. Medical comorbidities (p = 0.035) significantly predicted the change in MoCA score over time, while fat mass (FM, p = 0.518), Mediterranean diet index (p = .0.944), and Florida Cognitive Activities Score (p = 0.927) did not. These results suggest that the patients’ medical comorbidities at the time of SARS-CoV-2 infection could importantly contribute to the acute impairment of cognitive function and stress the importance of systemic implementation of countermeasures to limit the negative consequences on public health.
Keywords:Coronavirus, recovery, acute respiratory sindrom, cognitive functions, cognitive impairment, MOCA, trail-making test
Article acceptance date:19.04.2023
Publication date:26.05.2023
Year of publishing:2023
Number of pages:10 str.
Numbering:Vol. 14, [article no.] ǂ1141809
PID:20.500.12556/DiRROS-16611 New window
UDC:616.98:578.834:159.955
ISSN on article:1664-1078
DOI:10.3389/fpsyg.2023.1141809 New window
COBISS.SI-ID:153839363 New window
Copyright:© 2023 Peskar, Šimunič, Šlosar, Pišot, Teraž, Gasparini, Pišot and Marušič
Note:Nasl. z nasl. zaslona; Soavtorji: Boštjan Šimunič, Luka Šlosar, Saša Pišot, Kaja Teraž, Mladen Gasparini, Rado Pišot, Uroš Marušič; Opis vira z dne 30. 5. 2023;
Publication date in DiRROS:01.06.2023
Views:902
Downloads:420
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Record is a part of a journal

Title:Frontiers in psychology
Shortened title:Front. psychol.
Publisher:Frontiers Research Foundation
ISSN:1664-1078
COBISS.SI-ID:519967513 New window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:26.05.2023

Secondary language

Language:Slovenian
Keywords:okrevanje, akutni respiratorni sindrom, kognitivne funkcije, kognitivne motnje


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