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Title:Trends and timing of risk-reducing mastectomy uptake in unaffected BRCA1 and BRCA2 carriers in Slovenia
Authors:ID Ložar, Taja (Author)
ID Žgajnar, Janez (Author)
ID Perhavec, Andraž (Author)
ID Blatnik, Ana (Author)
ID Novaković, Srdjan (Author)
ID Krajc, Mateja (Author)
Files:.pdf PDF - Presentation file, download (593,94 KB)
MD5: BDA36785F3DD243F7F1425971F143E8F
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo OI - Institute of Oncology
Abstract:Objectives. Risk-reducing mastectomy (RRM) is one of key prevention strategies in female carriers of germline BRCA pathogenic/likely pathogenic variants (PV/LPV). We retrospectively investigated the rate, timing and longitudinal trends of bilateral RRM uptake and the incidence and types of cancers among unaffected BRCA carriers who underwent genetic counseling at the Institute of Oncology Ljubljana in Slovenia. Materials and Methods. Female BRCA carriers without personal history of cancer were included in the study. Clinical data on PV/LPV type, date of RRM, type of reconstructive procedure, occult carcinoma and histopathology results was collected and analyzed. Results. Of the 346 unaffected BRCA carriers (median age 43 years, 70% BRCA1, 30% BRCA2, median follow-up 46 months) who underwent genetic testing between October 1999 and December 2019, 25.1% had a RRM (range 35-50 years, median age at surgery 38 years). A significant difference in time to prophylactic surgery between women undergoing RRM only vs. women undergoing RRM combined with risk-reducing salpingo-oophorectomy was observed (22.6 vs 8.7 months, p=0.0009). We observed an upward trend in the annual uptake in line with the previously observed Angelina Jolie effect. In 5.7% of cases, occult breast cancer was detected. No women developed breast cancer after RRM. Women who did not opt for surgical prevention developed BRCA1/2-related cancers (9.3%). Conclusion. The uptake of RRM among unaffected BRCA carriers is 25.1% and is similar to our neighboring countries. No women developed breast cancer after RRM while women who did not opt for surgical prevention developed BRCA1/2 related cancers in 9.3% of cases. The reported data may provide meaningful aid for carriers when deciding on an optimal prevention strategy.
Keywords:risk-reducing mastectomy, breast cancer, BRCA
Publication status:Published
Publication version:Version of Record
Publication date:26.03.2021
Publisher:Elsevier
Year of publishing:2021
Number of pages:str. 1900-1906
Numbering:Vol. 47, no. 8
PID:20.500.12556/DiRROS-15566 New window
UDC:616-089
ISSN on article:0748-7983
DOI:10.1016/j.ejso.2021.03.248 New window
COBISS.SI-ID:57272579 New window
Copyright:by Authors
Publication date in DiRROS:21.09.2022
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Downloads:296
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Record is a part of a journal

Title:European journal of surgical oncology
Shortened title:Eur. j. surg. oncol.
Publisher:Academic Press
ISSN:0748-7983
COBISS.SI-ID:6045447 New window

Document is financed by a project

Funder:ARRS - Slovenian Research Agency
Project number:P3-0352-2018
Name:Družine s povišano ali visoko ogroženostjo za raka: svetovanje, odkrivanje mutacij in preprečevanje raka

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:21.09.2022

Secondary language

Language:Slovenian
Keywords:preventivna mastektomija, rak dojke, BRCA, gen BRCA


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