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Title:Risk factors for systemic reactions in typical cold urticaria : results from the COLD-CE study
Authors:ID Bizjak, Mojca, Klinika Golnik, Medicinska fakulteta UM (Author)
ID Košnik, Mitja, Klinika Golnik, Medicinska fakulteta UL (Author)
ID Dinevski, Dejan, Medicinska fakulteta UM (Author)
ID Thomsen, Simon Francis (Author)
ID Fomina, Daria (Author)
ID Borzova, Elena (Author)
ID Kulthanan, Kanokvalai (Author)
ID Meshkova, Raisa (Author)
ID Ahsan, Dalia Melina (Author)
ID Al-Ahmad, Mona (Author)
ID Miljković, Jovan, Medicinska fakulteta UM (Author)
ID Terhorst, Dorothea (Author)
ID Maurer, Marcus (Author)
Files:URL URL - Source URL, visit
Description: Dostopno z geslom
Typology:1.01 - Original Scientific Article
Organization:Logo UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
Abstract:Background. Cold urticaria (ColdU), i.e. the occurrence of wheals or angioedema in response to cold exposure, is classified into typical and atypical forms. The diagnosis of typical ColdU relies on whealing in response to local cold stimulation testing (CST). It can also manifest with cold-induced anaphylaxis (ColdA). We aimed to determine risk factors for ColdA in typical ColdU. Methods. An international, cross-sectional study COLD-CE was carried out at 32 urticaria centers of reference and excellence (UCAREs). Detailed history was taken and CST with an ice cube and/or TempTest® performed. ColdA was defined as an acute cold-induced involvement of the skin and/or visible mucosal tissue and at least one of: cardiovascular manifestations, difficulty breathing, or gastrointestinal symptoms. Results. Of 551 ColdU patients, 75% (n=412) had a positive CST and ColdA occurred in 37% (n=151) of the latter. Cold-induced generalized wheals, angioedema, acral swelling, oropharyngeal/laryngeal symptoms, and itch of earlobes were identified as signs/symptoms of severe disease. ColdA was most commonly provoked by complete cold water immersion and ColdA caused by cold air was more common in countries with a warmer climate. Ten percent (n=40) of typical ColdU patients had a concomitant chronic spontaneous urticaria (CSU). They had a lower frequency of ColdA than those without CSU (4% vs 39%, p=0.003). We identified the following risk factors for cardiovascular manifestations: previous systemic reaction to a Hymenoptera sting, angioedema, oropharyngeal/laryngeal symptoms, and itchy earlobes. Conclusion. ColdA is common in typical ColdU. High-risk patients require education about their condition and how to use an adrenaline autoinjector.
Keywords:urticaria, risk factors, epinephrine - therapeutic use, self administration, intramuscular injections - methods, cold urticaria, systemic reactions, adrenaline autoinjector
Article acceptance date:20.11.2021
Publication date:04.12.2021
Place of publishing:Velika Britanija
Year of publishing:2022
Number of pages:str. 2185-2199
Numbering:Vol. 77, iss. 7
PID:20.500.12556/DiRROS-15409 New window
ISSN on article:1398-9995
DOI:10.1111/all.15194 New window
COBISS.SI-ID:88071683 New window
Copyright:© 2021 The Authors
Note:Nasl. z nasl. zaslona; Soavtorji iz Slovenije: Mitja Košnik, Dejan Dinevski, Jovan Miljković; Opis vira z dne 6. 12. 2021;
Publication date in DiRROS:31.08.2022
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COBISS.SI-ID:515009305 New window


License:CC BY-NC 4.0, Creative Commons Attribution-NonCommercial 4.0 International
Description:A creative commons license that bans commercial use, but the users don’t have to license their derivative works on the same terms.
Licensing start date:04.12.2021

Secondary language

Title:Risk factors for systemic reactions in typical cold urticaria: results from the COLD-CE study
Keywords:koprivnica, urtikarija, dejavniki tveganja, adrenalin - terapevtska raba, avtoadministracija, intramuskularne injekcije - metode, urtikarija zaradi mraza, sistemske reakcije, avtoinjektor adrenalina