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Title:Allergies and COVID-19 vaccines : an ENDA/EAACI position paper
Authors:ID Barbaud, Annick (Author)
ID Garvey, Lene Heise (Author)
ID Arcolaci, Alessandra (Author)
ID Brockow, Knut (Author)
ID Mori, Francesca (Author)
ID Mayorga, Cristobalina (Author)
ID Jošt, Maja, Klinika Golnik (Author)
ID Košnik, Mitja, Klinika Golnik, Medicinska fakulteta UL (Author)
ID Zidarn, Mihaela, Klinika Golnik, Medicinska fakulteta UL (Author)
ID Torres, Maria J (Author)
Files:URL URL - Source URL, visit
Typology:1.01 - Original Scientific Article
Organization:Logo UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
Abstract:Anaphylaxis, which is rare, has been reported after COVID 19 vaccination, but its management is not standardized. Method. Members of the European Network for Drug Allergy and the European Academy of Allergy and Clinical Immunology interested in drug allergy participated in an online questionnaire on pre-vaccination screening and management of allergic reactions to COVID-19 vaccines, and literature was analysed. Results. No death due to anaphylaxis to COVID-19 vaccines has been confirmed in scientific literature. Potential allergens, polyethylene glycol (PEG), polysorbate and tromethamine, are excipients. The authors propose allergy evaluation of persons with the following histories: 1- anaphylaxis to injectable drug or vaccine containing PEG or derivatives; 2- anaphylaxis to oral/topical PEG containing products; 3-recurrent anaphylaxis of unknown cause; 4-suspected or confirmed allergy to any mRNA vaccine, 5-confirmed allergy to PEG or derivatives. We recommend a prick-to-prick skin test with the left over solution in the suspected vaccine vial to avoid waste. Prick test panel should include PEG 4000 or 3500, PEG 2000 and polysorbate 80. The value of in vitro test is arguable. Conclusions. These recommendations will lead to a better knowledge of the management and mechanisms involved in anaphylaxis to COVID-19 vaccines and enable more people with history of allergy to be vaccinated.
Keywords:SARS-CoV-2, COVID-19, COVID-19 vaccines, allergens, anapylaxis, drug hypersensitivity
Year of publishing:2022
Publication status in journal:In print
Article version:Postprint, final article version, accepted into publication
Number of pages:str. [1-58]
Numbering:Vol. 77, iss.
ISSN on article:1398-9995
DOI:10.1111/all.15241 New window
COBISS.SI-ID:96566531 New window
Note:Nasl. z nasl. zaslona; Soavtorji iz Slovenije: Maja Jošt, Mitja Košnik, Mihaela Zidarn; Opis vira z dne 7. 2. 2022;
Publication date in DiRROS:07.02.2022
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COBISS.SI-ID:515009305 New window

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Keywords:SARS-CoV-2, covid-19, cepiva proti covidu-19, alergeni, anafilaksija, preobčutljivost za zdravila