| Title: | Heterogeneous response of airway eosinophilia to anti-IL-5 biologics in severe asthma patients |
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| Authors: | ID Kopač, Maruša (Author)
ID Rijavec, Matija (Author)
ID Korošec, Peter (Author)
ID Bidovec, Urška (Author)
ID Kern, Izidor (Author)
ID Vantur, Romana (Author)
ID Škrgat, Sabina (Author) |
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| Files: |  PDF - Presentation file, download (805,99 KB)
MD5: 2D1E19734BDB21EEC30F6F74C9643323
 URL - Source URL, visit https://www.mdpi.com/2075-4426/12/1/70
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
 UKC LJ - Ljubljana University Medical Centre
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| Abstract: | Many questions concerning responders (R) and nonresponders (NR) in severe eosinophilic asthma (SEA) after blocking the IL-5 (interleukin 5) pathway are still not clear, especially regarding the early parameters of response to biologics in personalized treatment strategies. We evaluated 17 SEA patients treated with anti-IL-5 biologics (16 patients mepolizumab, one patient benralizumab) before the introduction of biologics, and at a week 16 follow-up. Clinical, cellular and immunological parameters in peripheral blood were measured in R and NR. Sputum induction with the measurement of cellular and immunological parameters was performed at 16 weeks only. There were 12 R and 5 NR to biologics. After 16 weeks, there was a significant improvement in percentages of FEV1 (p = 0.001), and asthma control test (ACT) (p = 0.001) in the R group, but not in NR. After 16 weeks, the eosinophils in induced sputum were 27.0% in NR and 4.5% in R (p = 0.05), with no difference in IL-5 concentrations (p = 0.743). Peripheral eosinophilia decreased significantly in NR (p = 0.032) and R (p = 0.002). In patients with SEA on anti-IL-5 therapy, there was a marked difference in airway eosinophilic inflammation between R and NR already at 16 weeks, after anti-IL-5 introduction. |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 01.01.2022 |
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| Place of publishing: | Švica |
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| Publisher: | MDPI |
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| Year of publishing: | 2022 |
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| Number of pages: | str. 1-12 |
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| Numbering: | Vol. 12, iss. 1 |
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| PID: | 20.500.12556/DiRROS-14720  |
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| UDC: | 616.2 |
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| ISSN on article: | 2075-4426 |
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| DOI: | 10.3390/jpm12010070 |
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| COBISS.SI-ID: | 92821507 |
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| Copyright: | © 2022 by the authors |
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| Note: | Nasl. z nasl. zaslona;
Maruša Kopač Šokić in Matija Rijavec sta enakovredna prva avtorja;
Opis z dne 11. 1. 2022;
Članek št. 70; |
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| Publication date in DiRROS: | 13.01.2022 |
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| Views: | 2651 |
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| Downloads: | 1518 |
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