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Title:Reduced parasympathetic reactivation during recovery from exercise in myalgic encephalomyelitis/chronic fatigue syndrome
Authors:Van Oosterwijck, Jessica (Author)
Marušič, Uroš (Author)
De Wandele, Inge (Author)
Meeus, Mira (Author)
Paul, Lorna (Author)
Lambrecht, Luc (Author)
Moorkens, Greta (Author)
Danneels, Lieven (Author)
Nijs, Jo (Author)
Language:English
Tipology:1.01 - Original Scientific Article
Organisation:Logo ZRS Koper - Science and Research Centre Koper
Abstract:Although autonomic nervous system (ANS) dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) has been proposed, conflicting evidence makes it difficult to draw firm conclusions regarding ANS activity at rest in ME/CFS patients. Although severe exercise intolerance is one of the core features of ME/CFS, little attempts have been made to study ANS responses to physical exercise. Therefore, impairments in ANS activation at rest and following exercise were examined using a case-control study in 20 ME/CFS patients and 20 healthy people. Different autonomous variables, including cardiac, respiratory, and electrodermal responses were assessed at rest and following an acute exercise bout. At rest, parameters in the time-domain represented normal autonomic function in ME/CFS, while frequency-domain parameters indicated the possible presence of diminished (para)sympathetic activation. Reduced parasympathetic reactivation during recovery from exercise was observed in ME/CFS. This is the first study showing reduced parasympathetic reactivation during recovery from physical exercise in ME/CFS. Delayed HR recovery and/or a reduced HRV as seen in ME/CFS have been associated with poor disease prognosis, high risk for adverse cardiac events, and morbidity in other pathologies, implying that future studies should examine whether this is also the case in ME/CFS and how to safely improve HR recovery in this population.
Keywords:autonomic nervous system, autonomic function, electrodermal activity, electrocardiogram, heart rate, physical activity
Year of publishing:2021
COBISS_ID:81462787 Link is opened in a new window
UDC:616.8:796.01
ISSN on article:2077-0383
DOI:10.3390/jcm10194527 Link is opened in a new window
Note:Nasl. z nasl. zaslona; Soavtorji: Uros Marusic, Inge De Wandele, Mira Meeus, Lorna Paul, Luc Lambrecht, Greta Moorkens, Lieven Danneels, Jo Nijs; Opis vira z dne 19. 10. 2021; Članek št. 4527;
Views:391
Downloads:241
Files:.pdf PDF - Presentation file, download (4,50 MB)
URL URL - Source URL, visit https://www.mdpi.com/2077-0383/10/19/4527
 
Journal:J. clin. med.
MDPI
 
Metadata:XML RDF-CHPDL DC-XML DC-RDF
Rights:2021 by the authors
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License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:30.09.2020

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