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Title:Cold agglutinins and cryoglobulins associate with clinical and laboratory parameters of cold urticaria
Authors:ID Bizjak, Mojca, Klinika Golnik (Author)
ID Košnik, Mitja, Klinika Golnik, Medicinska fakulteta UL (Author)
ID Terhorst, Dorothea (Author)
ID Dinevski, Dejan (Author)
ID Maurer, Marcus (Author)
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Typology:1.01 - Original Scientific Article
Organization:Logo UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
Abstract:Mast cell-activating signals in cold urticaria are not yet well defined and are likely to be heterogeneous. Cold agglutinins and cryoglobulins have been described as factors possibly associated with cold urticaria, but their relevance has not been explained. We performed a single-center prospective cohort study of 35 cold urticaria patients. Cold agglutinin and cryoglobulin test results, demographics, detailed history data, cold stimulation test results, complete blood count values, C-reactive protein, total immunoglobulin E levels, and basal serum tryptase levels were analyzed. Forty six percent (n = 16) of 35 tested patients had a positive cold agglutinin test and 27% (n = 9) of 33 tested patients had a positive cryoglobulin test. Cold agglutinin positive patients, when compared to cold agglutinin negative ones, were mainly female (P = 0.030). No gender-association was found for cryoglobulins. A positive cold agglutinin test, but not a positive cryoglobulin test, was associated with a higher rate of reactions triggered by cold ambient air (P = 0.009) or immersion in cold water (P = 0.041), and aggravated by increased summer humidity (P = 0.007). Additionally, patients with a positive cold agglutinin test had a higher frequency of angioedema triggered by ingestion of cold foods or drinks (P = 0.043), and lower disease control based on Urticaria Control Test (P = 0.023). Cold agglutinin levels correlated with erythrocyte counts (r = -0.372, P = 0.028) and monocyte counts (r = -0.425, P = 0.011). Cryoglobulin concentrations correlated with basal serum tryptase levels (r = 0.733, P = 0.025) and cold urticaria duration (r = 0.683, P = 0.042). Results of our study suggest that cold agglutinins and cryoglobulins, in a subpopulation of cold urticaria patients, are linked to the course and possibly the pathogenesis of their disease.
Keywords:urticaria, mast cells, cold-induced urticaria, cold urticaria, cryoglobulins, cold agglutinin, degranulation, clinical parameters, laboratory parameters
Year of publishing:2021
Publication status in journal:Published
Article version:Publisher's version of article
Publisher:Frontiers Media SA
Number of pages:str. 1-9
Numbering:[Vol.] 12
PID:20.500.12556/DiRROS-13941 New window
ISSN on article:1664-3224
DOI:10.3389/fimmu.2021.665491 New window
COBISS.SI-ID:61629187 New window
Copyright:© 2021 Bizjak, Košnik, Terhorst-Molawi, Dinevski and Maurer
Note:Nasl. z nasl. zaslona; Soavtorja iz Slovenije: Mitja Košnik, Dejan Dinevski; Opis vira z dne 3. 5. 2021; Št. prispevka: 665491;
Publication date in DiRROS:10.05.2021
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Record is a part of a journal

Title:Frontiers in immunology
Shortened title:Front. immunol.
Publisher:Frontiers Research Foundation
COBISS.SI-ID:30774233 New window


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:29.04.2021

Secondary language

Keywords:urtikarija, mastociti, urtikarija zaradi mraza, koprivnica, krioglobulini, hladni aglutinini, degranulacija, klinični parametri, laboratorijski parametri