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Title:Advance care planning in patients with advanced cancer : a 6-country, cluster-randomised clinical trial
Authors:Korfage, Ida Joanna (Author)
Carreras, Giulia (Author)
Arnfeldt Christiansen, Caroline M. (Author)
Billekens, Pascalle (Author)
Bramley, Louise (Author)
Briggs, Linda (Author)
Bulli, Francesco (Author)
Caswell, Glenys (Author)
Červ, Branka (Author)
Delden, Johannes JM van (Author)
Kodba Čeh, Hana (Author)
Lunder, Urška (Author)
Mimič, Alenka (Author)
Ozbič, Polona (Author)
Simonič, Anja (Author)
Language:English
Tipology:1.02 - Review Article
Organisation:Logo UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
Abstract:Background. Advance care planning (ACP) supports individuals to define, discuss, and record goals and preferences for future medical treatment and care. Despite being internationally recommended, randomised clinical trials of ACP in patients with advanced cancer are scarce. Methods and findings. To test the implementation of ACP in patients with advanced cancer, we conducted a cluster-randomised trial in 23 hospitals across Belgium, Denmark, Italy, Netherlands, Slovenia, and United Kingdom in 2015–2018. Patients with advanced lung (stage III/IV) or colorectal (stage IV) cancer, WHO performance status 0–3, and at least 3 months life expectancy were eligible. The ACTION Respecting Choices ACP intervention as offered to patients in the intervention arm included scripted ACP conversations between patients, family members, and certified facilitators; standardised leaflets; and standardised advance directives. Control patients received care as usual. Main outcome measures were quality of life (operationalised as European Organisation for Research and Treatment of Cancer [EORTC] emotional functioning) and symptoms. Secondary outcomes were coping, patient satisfaction, shared decision-making, patient involvement in decision-making, inclusion of advance directives (ADs) in hospital files, and use of hospital care. In all, 1,117 patients were included (442 intervention; 675 control), and 809 (72%) completed the 12-week questionnaire. Patients’ age ranged from 18 to 91 years, with a mean of 66; 39% were female. The mean number of ACP conversations per patient was 1.3. Fidelity was 86%. Sixteen percent of patients found ACP conversations distressing. Mean change in patients’ quality of life did not differ between intervention and control groups (T-score −1.8 versus −0.8, p = 0.59), nor did changes in symptoms, coping, patient satisfaction, and shared decision-making. Specialist palliative care (37% versus 27%, p = 0.002) and AD inclusion in hospital files (10% versus 3%, p < 0.001) were more likely in the intervention group. A key limitation of the study is that recruitment rates were lower in intervention than in control hospitals. Conclusions. Our results show that quality of life effects were not different between patients who had ACP conversations and those who received usual care. The increased use of specialist palliative care and AD inclusion in hospital files of intervention patients is meaningful and requires further study. Our findings suggest that alternative approaches to support patient-centred end-of-life care in this population are needed.
Keywords:advanced care planning, medical treatment, advanced cancer, palliative care
Year of publishing:2020
Publisher:Public Library of Science
Source:ZDA
COBISS_ID:38458371 Link is opened in a new window
UDC:616
ISSN on article:1549-1676
OceCobissID:2944020 Link is opened in a new window
DOI:10.1371/journal.pmed.1003422 Link is opened in a new window
Note:Nasl. z nasl. zaslona; Opis vira z dne 20. 11. 2020; Soavtorice iz Slovenije: Branka Červ, Hana Kodba-Čeh, Urška Lunder, Alenka Mimić, Polona Ozbič, Anja Simonič;
Views:755
Downloads:636
Files:.pdf PDF - Presentation file, download (986,49 KB)
.zip ZIP - Supplement, download (109,25 KB)
URL URL - Source URL, visit https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003208
 
Journal:PLoS med.
Public Library of Science
 
Metadata:XML RDF-CHPDL DC-XML DC-RDF
Rights:© 2020 Korfage et al.
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Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:13.11.2020

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