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Title:Cold urticaria : what we know and what we do not know
Authors:ID Maltseva, Natalya (Author)
ID Borzova, Elena (Author)
ID Fomina, Daria (Author)
ID Bizjak, Mojca, Klinika Golnik (Author)
ID Terhorst, Dorothea (Author)
ID Košnik, Mitja, Klinika Golnik, Medicinska fakulteta UL (Author)
ID Kulthanan, Kanokvalai (Author)
ID Meshkova, Raisa (Author)
ID Thomsen, Simon Francis (Author)
ID Maurer, Marcus (Author)
Files:URL URL - Source URL, visit
Typology:1.01 - Original Scientific Article
Organization:Logo UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
Abstract:Cold urticaria (ColdU) is a common form of chronic inducible urticaria characterised by the development of wheals, angioedema or both in response to cold exposure. Recent research and guideline updates have advanced our understanding and management of ColdU. Today, its pathophysiology is thought to involve the cold-induced formation of autoallergens and IgE to these autoallergens, which provoke a release of proinflammatory mediators from skin mast cells. The classification of ColdU includes typical and atypical subtypes. We know that cold-induced wheals usually develop on rewarming and resolve within an hour and that anaphylaxis can occur. The diagnosis relies on the patient's history and cold stimulation testing. Additional diagnostic work-up, including a search for underlying infections, should only be done if indicated by the patient's history. The management of ColdU includes cold avoidance, the regular use of nonsedating antihistamines, and the off-label use of omalizumab. However, many questions regarding ColdU remain unanswered. Here, we review what is known about ColdU, and we present important unanswered questions on the epidemiology, underlying pathomechanisms, clinical heterogeneity and treatment outcomes. Our aim is to guide future efforts that will close these knowledge gaps and advance the management of ColdU.
Keywords:urticaria, cryopyrin-associated periodic syndromes, cold-induced urticaria, familial cold autoinflammatory syndrome, cold stimulation testing, wheals, cryoglobulinemic vasculitis, cryoglobulins
Publication status in journal:In print
Article version:Postprint, final article version, accepted into publication
Place of publishing:Velika Britanija
Publisher:John Wiley & Sons
Year of publishing:2020
Number of pages:str. [1-45]
Numbering:Vol. 75, iss.
PID:20.500.12556/DiRROS-12896 New window
ISSN on article:1398-9995
DOI:10.1111/all.14674 New window
COBISS.SI-ID:41305859 New window
Copyright:© John Wiley & Sons
Note:Nasl. z nasl. zaslona; Soavtorja iz Slovenije: Mojca Bizjak, Mitja Košnik; Opis vira z dne 7. 12. 2020;
Publication date in DiRROS:14.12.2020
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COBISS.SI-ID:515009305 New window

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Keywords:urtikarija, periodični vročinski sindrom, povezan s kriopirino, murtikarija zaradi mraza, družinska urtikarija zaradi mraza, koprivnica, provokacijski test, izpuščaj, krioglobulinemični vaskulitis, krioglobulini