Digital repository of Slovenian research organisations

Show document
A+ | A- | SLO | ENG

Title:Cold urticaria : what we know and what we do not know
Authors:Maltseva, Natalya (Author)
Borzova, Elena (Author)
Fomina, Daria (Author)
Bizjak, Mojca (Author)
Terhorst, Dorothea (Author)
Košnik, Mitja (Author)
Kulthanan, Kanokvalai (Author)
Meshkova, Raisa (Author)
Thomsen, Simon Francis (Author)
Maurer, Marcus (Author)
Language:English
Tipology:1.01 - Original Scientific Article
Organisation:Logo UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
Abstract:Cold urticaria (ColdU) is a common form of chronic inducible urticaria characterised by the development of wheals, angioedema or both in response to cold exposure. Recent research and guideline updates have advanced our understanding and management of ColdU. Today, its pathophysiology is thought to involve the cold-induced formation of autoallergens and IgE to these autoallergens, which provoke a release of proinflammatory mediators from skin mast cells. The classification of ColdU includes typical and atypical subtypes. We know that cold-induced wheals usually develop on rewarming and resolve within an hour and that anaphylaxis can occur. The diagnosis relies on the patient's history and cold stimulation testing. Additional diagnostic work-up, including a search for underlying infections, should only be done if indicated by the patient's history. The management of ColdU includes cold avoidance, the regular use of nonsedating antihistamines, and the off-label use of omalizumab. However, many questions regarding ColdU remain unanswered. Here, we review what is known about ColdU, and we present important unanswered questions on the epidemiology, underlying pathomechanisms, clinical heterogeneity and treatment outcomes. Our aim is to guide future efforts that will close these knowledge gaps and advance the management of ColdU.
Keywords:urticaria, cryopyrin-associated periodic syndromes, cold-induced urticaria, familial cold autoinflammatory syndrome, cold stimulation testing, wheals, cryoglobulinemic vasculitis, cryoglobulins
Year of publishing:2020
Publisher:John Wiley & Sons
Source:Velika Britanija
COBISS_ID:41305859 Link is opened in a new window
UDC:616-097
ISSN on article:1398-9995
OceCobissID:515009305 Link is opened in a new window
DOI:10.1111/all.14674 Link is opened in a new window
Note:Nasl. z nasl. zaslona; Soavtorja iz Slovenije: Mojca Bizjak, Mitja Košnik; Opis vira z dne 7. 12. 2020;
Views:697
Downloads:197
Files:URL URL - Source URL, visit https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.14674
 
Journal:Allergy
Blackwell
 
Metadata:XML RDF-CHPDL DC-XML DC-RDF
Rights:© John Wiley & Sons
:
  
Hover the mouse pointer over a document title to show the abstract or click on the title to get all document metadata.


Back