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Title:Heat shock protein 27 as a predictor of prognosis in patients admitted to hospital with acute COPD exacerbation
Authors:Zimmermann, Matthias (Author)
Traxler, Denise (Author)
Bekos, Christine (Author)
Simader, Elisabeth (Author)
Mueller, Thomas (Author)
Graf, Alexandra (Author)
Lainščak, Mitja (Author)
Marčun, Robert (Author)
Košnik, Mitja (Author)
Fležar, Matjaž (Author)
Rozman, Aleš (Author)
Korošec, Peter (Author)
Language:English
Tipology:1.01 - Original Scientific Article
Organisation:Logo UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
Abstract:Episodes of acute exacerbations are major drivers of hospitalisation and death from COPD. To date, there are no objective biomarkers of disease activity or biomarkers to predict patient outcome. In this study, 211 patients hospitalised for an acute exacerbation of COPD have been included. At the time of admission,routine blood tests have been performed including complete blood count, C-reactive protein, cardiac troponin T and NT-proBNP. Heat shock protein 27 (HSP27) serum concentrations were determined at time of admission, discharge and 180 days after discharge by ELISA. We were able to demonstrate significantly increased HSP27 serum concentrations in COPD patients at time of admission to hospital as compared to HSP27 concentrations obtained 180 days after discharge. In univariable Cox regression analyses, a HSP27 serum concentration >/= 3098 pg/mL determined at admission was a predictor of all-cause mortality at 90 days, 180 days, 1 year and 3 years. In multivariable analyses, an increased HSP27 serum concentration at admission retained its prognostic ability with respect to all-cause mortality for up to 1year follow-up. However, an increased HSP27 serum concentration at admission was not an independent predictor of long-term all-cause mortality at 3 years. Elevated serum HSP27 concentrations significantly predicted short-term mortality in patients admitted to hospital with acute exacerbation of COPD and could help to improve outcomes by identifying high-risk patients.
Keywords:COPD, acute exacerbation, disease activity
Year of publishing:2020
Publisher:Springer
Source:ZDA
COBISS_ID:2048610673 Link is opened in a new window
UDC:616.2
ISSN on article:1466-1268
OceCobissID:515403545 Link is opened in a new window
DOI:10.1007/s12192-019-01057-0 Link is opened in a new window
Note:Nasl. z nasl. zaslona; Soavtorji iz Slovenije: Mitja Lainscak, Robert Marčun, Mitja Košnik, Matjaž Fležar, Aleš Rozman, Peter Korošec; Opis vira z dne 8. 1. 2020;
Views:512
Downloads:206
Files:URL URL - Presentation file, visit https://link.springer.com/content/pdf/10.1007/s12192-019-01057-0.pdf
 
Journal:Cell stress chaperones
Churchill Livingstone
 
Metadata:XML RDF-CHPDL DC-XML DC-RDF
Rights:The Author(s) 2019
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Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:29.07.2020

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