| Title: | Heat shock protein 27 as a predictor of prognosis in patients admitted to hospital with acute COPD exacerbation |
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| Authors: | ID Zimmermann, Matthias (Author)
ID Traxler, Denise (Author)
ID Bekos, Christine (Author)
ID Simader, Elisabeth (Author)
ID Mueller, Thomas (Author)
ID Graf, Alexandra (Author)
ID Lainščak, Mitja (Author)
ID Marčun, Robert, Klinika Golnik, Medicinska fakulteta UL (Author)
ID Košnik, Mitja, Klinika Golnik, Medicinska Fakulteta UL (Author)
ID Fležar, Matjaž, Klinika Golnik, Medicinska fakulteta UL (Author)
ID Rozman, Aleš, Klinika Golnik (Author)
ID Korošec, Peter, Klinika Golnik (Author) |
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| Files: |  PDF - Presentation file, download (679,90 KB)
MD5: 91BE12F2ECA3189122E6B975B59E547F
 URL - Source URL, visit https://link.springer.com/content/pdf/10.1007/s12192-019-01057-0.pdf
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
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| Abstract: | Episodes of acute exacerbations are major drivers of hospitalisation and death from COPD. To date, there are no objective biomarkers of disease activity or biomarkers to predict patient outcome. In this study, 211 patients hospitalised for an acute exacerbation of COPD have been included. At the time of admission,routine blood tests have been performed including complete blood count, C-reactive protein, cardiac troponin T and NT-proBNP. Heat shock protein 27 (HSP27) serum concentrations were determined at time of admission, discharge and 180 days after discharge by ELISA. We were able to demonstrate significantly increased HSP27 serum concentrations in COPD patients at time of admission to hospital as compared to HSP27 concentrations obtained 180 days after discharge. In univariable Cox regression analyses, a HSP27 serum concentration >/= 3098 pg/mL determined at admission was a predictor of all-cause mortality at 90 days, 180 days, 1 year and 3 years. In multivariable analyses, an increased HSP27 serum concentration at admission retained its prognostic ability with respect to all-cause mortality for up to 1year follow-up. However, an increased HSP27 serum concentration at admission was not an independent predictor of long-term all-cause mortality at 3 years. Elevated serum HSP27 concentrations significantly predicted short-term mortality in patients admitted to hospital with acute exacerbation of COPD and could help to improve outcomes by identifying high-risk patients. |
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| Keywords: | COPD, acute exacerbation, disease activity |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Place of publishing: | ZDA |
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| Publisher: | Springer |
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| Year of publishing: | 2020 |
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| Number of pages: | str. 141-149 |
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| Numbering: | Vol. 25, iss. |
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| PID: | 20.500.12556/DiRROS-12278  |
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| UDC: | 616.2 |
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| ISSN on article: | 1466-1268 |
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| DOI: | 10.1007/s12192-019-01057-0 |
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| COBISS.SI-ID: | 2048610673 |
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| Copyright: | The Author(s) 2019 |
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| Note: | Nasl. z nasl. zaslona;
Soavtorji iz Slovenije: Mitja Lainscak, Robert Marčun, Mitja Košnik, Matjaž Fležar, Aleš Rozman, Peter Korošec;
Opis vira z dne 8. 1. 2020; |
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| Publication date in DiRROS: | 29.07.2020 |
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| Views: | 1683 |
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| Downloads: | 1046 |
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