| Title: | Comparative analysis of prognostic histopathologic parameters in subtypes of epithelioid pleural mesothelioma |
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| Authors: | ID Bilecz, Agnes (Author)
ID Stockhammer, Paul (Author)
ID Theegarten, Dirk (Author)
ID Kern, Izidor, Klinika Golnik (Author)
ID Jakopović, Marko (Author)
ID Samaržija, Miroslav (Author)
ID Klikovits, Thomas (Author)
ID Hoda, Mir Alireza (Author)
ID Dome, Balazs (Author)
ID Oberndorfer, Felicitas (Author) |
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| Files: |  PDF - Presentation file, download (1,66 MB)
MD5: B44113E9F82E5BB2ECFD0D50988304DD
 ZIP - Supplement, download (2,16 MB)
MD5: 11E8F900D070B60826563DC49FD2C537
 URL - Source URL, visit https://onlinelibrary.wiley.com/doi/epdf/10.1111/his.14105
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
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| Abstract: | Malignant pleural mesothelioma (MPM) is a rare malignancy with a dismal prognosis. While the
epithelioid type is associated with a more favourable outcome, additional factors are needed to further stratify prognosis and to identify patients who can benefit from multimodal treatment. As epithelioid MPM shows remarkable morphological variability, the prognostic role of the five defined morphologies, the impact of the nuclear grading system and the mitosis-necrosis score were investigated in this study. Methods and results: Tumour specimens of 192 patients with epithelioid MPM from five European centres were histologically subtype d. Nuclear grading
and mitosis–necrosi s score were determined and correlated with clinicopathological parameters and overall survival (OS). Digital slides of 55 independent cases from The Cancer Genome Atlas (TCGA) database were evaluated for external validation. Histological subtypes were collapsed into three groups based on their overlapping survival curves. The tubulopapillary/microcystic group had a significantly longer OS than the solid/trabecular group (732 days versus 397 days, P = 0.0013). Pleomorphic tumours had the shortest OS (173 days). The solid/trabecular variants showed a significant association with high nuclear grade and mitosis – necrosis score. The mitosis–necrosis score was a robust and independent prognostic factor in our patient cohort. The prognos-
tic significance of all three parameters was externally validated in the TCGA cohort. Patients with tubulopapillary or microcystic tumours showed a greater improvement in OS after receiving multimodal therapy than those with solid or trabecular tumours. Conclusions: Histological subtypes of epithelioid MPM have a prognostic impact, and might help to select patients for intensive multimodal treatment approaches. |
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| Keywords: | epithelioid malignant pleural mesothelioma, histological subtypes |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Place of publishing: | ZDA |
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| Publisher: | John Wiley & Sons Ltd. |
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| Year of publishing: | 2020 |
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| Number of pages: | str. 55-66 |
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| Numbering: | Vol. 77, iss. 1 |
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| PID: | 20.500.12556/DiRROS-12164  |
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| UDC: | 616-006 |
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| ISSN on article: | 1365-2559 |
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| DOI: | 10.1111/his.14105 |
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| COBISS.SI-ID: | 2048642929 |
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| Copyright: | © 2020 The Authors |
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| Note: | Nasl. z nasl. zaslona;
Soavtor iz Slovenije: Izidor Kern;
Opis vira z dne 16. 3. 2020;
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| Publication date in DiRROS: | 08.07.2020 |
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| Views: | 2095 |
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| Downloads: | 1371 |
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